TAP2 Products

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq]

Bioinformatics

Entrez	6891 Human
Uniprot	ENSP00000372599 Human Q03519 Human
Product By Gene ID	6891
Alternate Names	ABCB3ABC18 antigen peptide transporter 2 APT2 ATP-binding cassette, sub-family B (MDR/TAP), member 3 D6S217E MHC 2 Peptide transporter involved in antigen processing 2 Peptide transporter PSF2 Peptide transporter TAP2 PSF2PSF-2 Really interesting new gene 11 protein RING11ATP-binding cassette sub-family B member 3 transporter 2, ABC (ATP binding cassette) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Y1