t-Plasminogen Activator/tPA Antibody (JF0958)

Immunohistochemistry-Paraffin: t-Plasminogen Activator/tPA Antibody (JF0958) [NBP2-67220] - Analysis of paraffin-embedded rat brain tissue using anti-PLAT antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: t-Plasminogen Activator/tPA Antibody (JF0958) [NBP2-67220] - Analysis of paraffin-embedded mouse brain tissue using anti-PLAT antibody. Counter stained with hematoxylin.

Product Discontinued

t-Plasminogen Activator/tPA Antibody (JF0958) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic peptide within Human t-Plasminogen Activator/tPA aa 523-562 / 562. (SwissProt: P00750 Human; SwissProt: P11214 Mouse; SwissProt: P19637 Rat)
• Localization: Secreted.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PLAT
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for t-Plasminogen Activator/tPA Antibody (JF0958)

• Alteplase
• DKFZp686I03148
• EC 3.4.21
• EC 3.4.21.68
• plasminogen activator, tissue type
• plasminogen activator, tissue
• PLAT
• Reteplase
• tissue plasminogen activator (t-PA)
• tissue-type plasminogen activator
• TPA
• T-PA
• tPlasminogen Activator
• t-Plasminogen Activator

Background

Tissue plasminogen activator (tPA) is a serine protease which converts the abundant proenzyme plasminogen to active plasmin. It plays a key role in thrombolysis (1) and several neurobiological processes (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for t-Plasminogen Activator/tPA Antibody (NBP2-67220)(2)

Publications using NBP2-67220

• Cardenas HL, Evanoff NG, Fandl HK et al. Endothelial derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function Journal of applied physiology (Bethesda, Md. : 1985) 2023-06-22 [PMID: 37348012]
• DeSouza NM, Brewster LM, Bain AR et al. Global reach 2018: Influence of excessive erythrocytosis on coagulation and fibrinolytic factors in andean highlanders Experimental physiology 2021-03-21 [PMID: 33745204]

Bioinformatics

• Gene Symbol: PLAT