SUZ12 Antibody (448909) [Alexa Fluor® 488]

• Applications: WB, IP, ICC/IF
• Clone: 448909
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

SUZ12 Antibody (448909) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human SUZ12
  Thr131-Asn305
  Accession # Q15022
• Specificity: Detects human SUZ12 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

SUZ12 (suppressor of zeste 12; also known as Joined to JazF1) is a 90-95 kDa member of the Polycomb group of transcriptional regulators. It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. Human SUZ12 is 739 amino acids (aa) in length. It contains one C2H2-type zinc finger region (aa 44-8471) and a C-terminal VEFS-box (aa 563-639). There is one potential splice form that shows a deletion of 51 aa over aa 129-197. Human SUZ12 shares 90% and 99% aa identity with mouse and dog SUZ12, respectively. Over the immunogen sequence in MAB4184, aa identity between human and mouse is 99%.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.