SUR-8 Antibody

Product Discontinued

SUR-8 Antibody Summary

• Immunogen: Synthetic peptide derived from N term parts of human protein.
• Specificity: Antibody reacts specifically with 65 kDa human protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SHOC2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot

Reactivity Notes

This product is reactive in Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Antiserum
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Lyophilized powder, reconstituted in distilled water.

Alternate Names for SUR-8 Antibody

• KIAA0862FLJ60412
• Protein soc-2 homolog
• Protein sur-8 homolog
• SIAA0862
• soc-2 (suppressor of clear, C.elegans) homolog
• soc-2 suppressor of clear homolog (C. elegans)
• SOC-2
• SOC2SUR8leucine-rich repeat protein SHOC-2
• SUR-8

Background

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SUR-8 Antibody (NBP1-48382)(2)

Publications using NBP1-48382

• He Z, Jiang J, Hofmann MC et al. Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod. 2007-10-01 [PMID: 17625109]
  
  Details:
  1. GFRA1 (IMG-192), Figs 1B, 5D (siRNA validated).
• Lozada A, Karlstedt K, Panula P et al. Unilateral labyrinthectomy induced changes on GDNF receptor complex proteins in the rat medial vestibular nuclei. J Vestib Res. 2006-01-01 [PMID: 17538205]

Bioinformatics

• Gene Symbol: SHOC2