SOCS-1 Antibody


Western Blot: SOCS-1 Antibody [NBP1-39570] - Analysis of anti-SOCS1 antibody with human spleen cell lysate at (A) 1, (B) 2 and (C) 4 ug/ml.
Immunohistochemistry-Paraffin: SOCS-1 Antibody [NBP1-39570] - Analysis of anti-SOCS1 antibody with human brain, cortex at concentration 5 ug/ml.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC-P
1 mg/ml

Order Details

SOCS-1 Antibody Summary

A synthetic peptide from human SOCS1.
15 amino acid peptide from near the carboxy terminus of human SOCS1
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified


  • Western Blot 1 - 2 ug/ml
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 5 ug/ml
Read Publication using
NBP1-39570 in the following applications:

  • WB
    1 publication

Alternate Names for SOCS-1 Antibody

  • CIS1
  • Cish1
  • JAB
  • JABTec-interacting protein 3
  • JAK binding protein
  • JAK-binding protein
  • SOCS1
  • SOCS-1CIS1
  • SSI-1
  • SSI-1CISH1
  • SSI1cytokine-inducible SH2 protein 1
  • STAT induced SH3 protein 1
  • STAT-induced STAT inhibitor 1
  • suppressor of cytokine signaling 1
  • TIP3
  • TIP-3
  • TIP3Cish1


Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways. Proteins that mediate these signals from the cell surface to the nucleus include Janus kinases, e.g., Janus kinase 1, and the signal transducers and activators of transcription (STATs), such as STAT1. To maintain tight control of these signal transduction pathways, mechanisms for turning off the signals are necessary. The adverse consequences of an imbalance between positive and negative signals is evident in the motheaten mouse, which lacks the phosphatase SHP1. These mice fail to regulate cytokine responses appropriately, resulting in hyperproliferation and accumulation of cells in several hematopoietic lineages and the development of systemic autoimmune disease. SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOCS-1 Antibody (NBP1-39570)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


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Contact Information

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Gene Symbol SOCS1

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