SMOC-2 Antibody (667713) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: IHC
• Clone: 667713
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

SMOC-2 Antibody (667713) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human SMOC-2
  Gln22-Gly446
  Accession # Q9H3U7
• Specificity: Detects human SMOC-2 in direct ELISAs and Western blots. In Western blots, approximately 15% cross-reactivity with recombinant human (rh) SMOC-1 and no cross-reactivity with recombinant mouse SMOC-2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SMOC-2 Antibody (667713) [Alexa Fluor® 405]

• bA270C4A.1
• bA37D8.1
• dJ421D16.1
• MST117
• MSTP117
• MSTP140
• SMAP2
• SMAP-2
• SMAP2Secreted modular calcium-binding protein 2
• SMOC2
• SMOC-2
• smooth muscle associated protein 2
• Smooth muscle-associated protein 2
• SPARC related modular calcium binding 2
• SPARC-related modular calcium-binding protein 2
• thyroglobulin type-1 repeat containing protein

Background

SMOC-2 (secreted modular calcium-binding protein 2; also SMAP2) is a 55 kDa glycoprotein member of the SPARC family of matricellular proteins.  It is widely expressed, perhaps by endothelium, and apparently participates in both growth factor signaling and ECM organization.  Mature human SMOC-2 is 425 amino acids (aa) in length.  It contains one Kazal-like domain (aa 40-84), two thyroglobulin type-1 segments (aa 87-153 and 213-281), and two EF-hand sequences (aa 347-382 and 384‑419).  There are three splice variants.  One shows a 13 aa substitution for aa 442-446, another shows an 11 aa insertion after Thr170, and a third represents a combination of the above two variations.  Over aa 22-446, human SMOC-2 shares 95% aa identity with mouse SMOC-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.