SLC39A14 Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: SLC39A14 Antibody [NBP1-81551] - Staining of human cell line A-431 shows localization to plasma membrane, endoplasmic reticulum & the Golgi apparatus. Antibody staining is shown in green.

Immunohistochemistry-Paraffin: SLC39A14 Antibody [NBP1-81551] - Staining of human small intestine shows strong cytoplasmic positivity in glandular cells.

Product Discontinued

SLC39A14 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: EHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSD
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC39A14
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:2500 - 1:5000
  • Immunohistochemistry-Paraffin 1:2500 - 1:5000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (89%), Rat (88%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for SLC39A14 Antibody - BSA Free

• Irt-like protein 14
• LIV-1 subfamily of ZIP zinc transporter 4
• LZT-Hs4
• solute carrier family 39 (metal ion transporter), member 14
• solute carrier family 39 (zinc transporter), member 14
• solute carrier family 39 member 14
• zinc transporter ZIP14
• ZIP14
• ZIP-14
• zrt- and Irt-like protein 14

Background

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 (PubMed 12659941)).(supplied by OMIM)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SLC39A14 Antibody (NBP1-81551)(1)

Publication using NBP1-81551

• Tuschl K, Meyer E, Valdivia LE et al. Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nat Commun. 2016-05-27 [PMID: 27231142] (IHC-P, Human)

Bioinformatics

• Gene Symbol: SLC39A14
• Entrez:
  • 23516(Human)
• Uniprot:
  • Q15043(Human)