SH2B1 Antibody (700320) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB
• Clone: 700320
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

SH2B1 Antibody (700320) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human SH2B1
  Pro317-Leu467
  Accession # Q9NRF2
• Specificity: Detects human SH2B1 in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SH2B1 Antibody (700320) [Alexa Fluor® 350]

• FLJ30542
• KIAA1299
• Pro-rich, PH and SH2 domain-containing signaling mediator
• PSM
• SH2 domain-containing protein 1B
• SH2 domain-containing putative adapter SH2-B
• SH2B adapter protein 1
• SH2B adaptor protein 1
• SH2-B signaling protein
• SH2B1
• SH2BDKFZp547G1110

Background

SH2B1 (SH2 adaptor protein B1), also called PSM (Pro-rich, PH and SH2 domain-containing signaling mediator) is an adaptor protein that mediates signaling between receptor tyrosine kinases and JAK signaling pathways. The 756 amino acid (aa) human SH2B1 contains an N-terminal Phe-zipper dimerization domain (aa 26-82), a nuclear localization sequence (aa 224-233), a PH domain (aa 267-376), and a pY-binding SH2 domain (aa 526-614). Within the region used as an immunogen, human SH2B1 shares 92% aa sequence identity with human and mouse SH2B1. Potential isoforms of 683 and 671 diverge after aa 632; a potential 426 aa form also shows an alternate start site at aa 246.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.