Serpin I2 Antibody (203402)

• Reactivity: Hu
• Applications: WB, IP
• Clone: 203402
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Serpin I2 Antibody (203402) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Serpin I2
• Specificity: Detects human Serpin I2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, C1, F2, I1, recombinant mouse (rm) Serpin D1, or rmPEDF is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SERPINI2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin I2 Antibody (203402)

• MEPI
• MEPIpancpin
• Myoepithelium-derived serine protease inhibitor
• Pancipin
• Pancpin
• Pancreas-specific protein TSA2004
• Peptidase inhibitor 14
• PI14
• PI-14
• PI14clade I (neuroserpin), member 2
• protease inhibitor 14
• serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
• Serpin I2
• serpin peptidase inhibitor, clade I (pancpin), member 2
• SERPIN12

Background

Serpin I2, also known as PI14 (proteinase inhibitor 14), pancipin or MEPI (myoepithelium-derived serine proteinase inhibitor), is an inhibitor of cell motility and metastasis and is a type 2 tumor suppressor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Serpin I2 Antibody (MAB2235)(1)

Publication using MAB2235

• Wayne J Higgins SerpinI2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin Biochim. Biophys. Acta, 2016-10-27;1865(2):195-200. 2016-10-27 [PMID: 27989643] (Immunoprecipitation)

Bioinformatics

• Gene Symbol: SERPINI2