Serpin I1/Neuroserpin Antibody (437016) [Alexa Fluor® 488]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 437016
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 488

Serpin I1/Neuroserpin Antibody (437016) [Alexa Fluor® 488] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Serpin I1
  Ala19-Leu410
  Accession # AAH18043
• Specificity: Detects human and mouse SerpinI1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross reactivity with recombinant mouse Serpin I1 is observed and no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A12
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin I1/Neuroserpin Antibody (437016) [Alexa Fluor® 488]

• DKFZp781N13156
• Neuroserpin
• Peptidase inhibitor 12
• PI12
• PI-12
• PI12Serpin I1
• serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
• Serpin I1
• serpin peptidase inhibitor, clade I (neuroserpin), member 1

Background

Serpin I1, also known as neuroserpin, is a secreted serine protease inhibitor predominantly expressed in the brain. Serpin I1 defects cause familial encephalopathy with neuroserpin inclusion bodies (FEN1B), an autosomal dominant dementia. The amino acid sequence of human Serpin I1 is 99%, 93%, 88%, 86% and 80% identical to that of chimpanzee, dog, rat, mouse and chicken.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • AAH18043()