Serpin B8/Proteinase Inhibitor 8 Antibody [Alexa Fluor™ Plus 594]

• Reactivity: Mu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 594

Serpin B8/Proteinase Inhibitor 8 Antibody [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects mouse Serpin B8/Proteinase Inhibitor 8 in direct ELISAs and Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) Serpin B8, rhSerpin B9, and rhSerpin B6 is observed and less than 1% cross-reactivity with rhSerpin A1, D1, E2, I2, recombinant mouse Serpin A1, C1, E1, F1, and F2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin B8/Proteinase Inhibitor 8 Antibody [Alexa Fluor™ Plus 594]

• CAP2
• CAP-2
• CAP2clade B (ovalbumin), member 8
• Cytoplasmic antiproteinase 2
• NK10
• Peptidase inhibitor 8
• PI8
• PI-8
• protease inhibitor 8 (ovalbumin type)
• Serpin B8
• serpin peptidase inhibitor, clade B (ovalbumin), member 8

Background

Serpin B8, also known as Proteinase Inhibitor 8 (PI8) and cytoplasmic antiproteinase 2 (CAP2), is a member of the Serpin superfamily of the serine protease inhibitors (1). It inhibits furin, a ubiquitously expressed convertase that processes many pro-proteins (2). Distribution of Serpin B8 alters during kidney regeneration, indicating that it plays a role in inflammation or tissue repair (3).

1. Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
2. Dahlen, J.R. et al. (1998) J. Biol. Chem. 273:1851.
3. Gillard, A. (2006) Am. J. Nephrol. 26:34.
.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.