Serpin A9/Centerin Antibody (585302) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: IHC
• Clone: 585302
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Serpin A9/Centerin Antibody (585302) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Serpin A9/Centerin
  Ala24-Thr417
  Accession # AAQ89063
• Specificity: Detects human Serpin A9/Centerin in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A6, A11, A12, B6, B8, B9, C1, D1, E1, E2, F1, F2, G1, I1, I2, recombinant mouse (rm) SerpinA3N, and rmSerpinA9
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A9/Centerin Antibody (585302) [Alexa Fluor® 405]

• Centerin
• GCET1
• Serpin A9
• SERPINA11
• SERPINA11b

Background

Serpin A9 (Serine proteinase inhibitor-clade A #9; also GCET1, Centerin and Serpin A11) is a 46 kDa, secreted member of the alpha 1-antitrypsin (clade A) subfamily, serpin superfamily of protease inhibitors. It is only produced by normal and lymphoma germinal center B cells. Its function is unknown, but it presumably acts as an inhibitor of a trypsin-like protease. Mature human Serpin A9 is presumably 394 amino acids (aa) in length. It contains one Serpin motif (aa 405-415). There are multiple splice variants associated with Serpin A9. There are alternate start sites at Met19, Met99 and Met150. A fourth isoform shows a two aa substitution for aa 369-435, while a fifth isoform shares this same substitution coupled with a 39 aa substitution for aa 1-75. A sixth variant shows a deletion of aa 91-190. Mature human Serpin A9 shares 67% aa identity with mouse Serpin A9.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.