S1P4/EDG-6 Antibody

Immunohistochemistry: S1P4/EDG-6 Antibody [NLS70] - Analysis of anti-S1PR4 / EDG6 antibody with human lymph node.

Product Discontinued

S1P4/EDG-6 Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from C-terminus of human S1P4/EDG-6.
• Localization: Integral membrane protein.
• Specificity: Human S1PR4 / EDG6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except C1orf65 (65%).
• Predicted Species: Mouse (94%), Bovine (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: S1PR4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 8 - 19 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Rat (88%), Opossum (88%), Hamster (82%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for S1P4/EDG-6 Antibody

• EDG6
• EDG6S1P receptor Edg-6
• Endothelial differentiation G-protein coupled receptor 6
• endothelial differentiation, G-protein-coupled receptor 6
• endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor6,endothelial differentiation, G protein coupled receptor 6
• S1P receptor 4
• S1P4
• S1P4LPC1
• S1PR4
• SLP4
• sphingosine 1-phosphate receptor 4
• Sphingosine 1-phosphate receptor Edg-6
• sphingosine-1-phosphate receptor 4

Background

EDG6, a Lysophospholipid/Lysosphingolipid Receptor, may regulate lymphocyte cell signaling. EDG6 is activated by sphingosine-1-phosphate. EDG6 has been reported in fetal and adult lymphoid and hematopoietic tissues (Graler et al, 1998) as well as in rat lung and Burkitt lymphoma cell lines. Contrary to other receptors of the EDG family, EDG6 is not expressed in the nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: S1PR4
• Uniprot:
  • O95977()