RUVBL1 Antibody


Western Blot: RUVBL1 Antibody [NBP2-27148] - Analysis of Rvb1 in human testis lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse testis and 4) rat testis lysate using this antibody. Goat more

Product Details

Reactivity HuSpecies Glossary
Applications WB
0.5 mg/ml

Order Details

RUVBL1 Antibody Summary

A portion of amino acids 1-50 of human Rvb1 was used as the immunogen.
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.2 ml PBS and 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Protein A purified


  • Western Blot 1:100-1:2000

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human, mouse and rat.

Alternate Names for RUVBL1 Antibody

  • 49 kDa TATA box-binding protein-interacting protein
  • 54 kDa erythrocyte cytosolic protein
  • EC 3.6.1
  • EC,49 kDa TBP-interacting protein
  • ECP54
  • INO80 complex subunit H
  • INO80HTIP49A
  • NMP 238
  • NMP238ECP-54
  • Nuclear matrix protein 238
  • Pontin 52
  • Pontin52
  • RuvB (E coli homolog)-like 1
  • RuvB-like 1 (E. coli)
  • ruvB-like 1
  • Rvb1
  • TATA binding protein interacting protein 49 kDa
  • TIH1
  • TIP49a
  • TIP49TAP54-alpha
  • TIP60-associated protein 54-alpha


RuvB-like1 (Rvb1) is a member of the AAA+ superfamily, and has both single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. AAA+ stands for "ATPases associated with diverse cellular activities and AAA+ family members share similarity in sequence and in structure. As a family, AAA+ proteins are involved in a large number of cellular functions in which energy extracted from ATP hydrolysis is used in molecular remodeling events (reviewed in Snider et al, 2008). Functional diversity and specificity of family members is obtained through the addition of structural motifs and modifications to a core AAA+ module as well as by the association of partner proteins and cofactors. Rvb1 and the closely related Rvb2 protein are both involved in chromatin remodeling, transcription, small nucleolar RNA maturation, cellular transformation, apoptosis, and mitosis (reviewed in Cheung et al, 2010 and Huen et al, 2010). Rvbs are capable of playing roles in such diverse cellular processes because they are components of a number of different macromolecular assemblies. For example, Rvbs are componentsof large chromatin-remodeling complexes including INO80, p400, and SWR1 and of chromatin-modifying enzymes such as the TIP60 complex. Rvbs are also found in RNA polymerase II and small nucleolar ribonucleoprotein complexes where they play roles in mediating transcription and nucelolar localization, respectively. Rvbs have roles in both transformation and apoptosis through their interaction with c-MYC, and in mitosis through their association with the mitotic spindle and centrosomes. Rvbs have been implicated in human pathologies, including carcinogenesis. For example Rvb1 overexpresssion has been reported in colon carcinoma, and Rvb1 SUMOylation has been shown to increase the proliferation and growth of prostate cancer cells. Rvb1 may also play a role in autoimmunity as high levels of RUVB1 autoantibodies have been detected in the sera of patients with autoimmune diseases including polymyositis/dermatomyosistic and autoimmune hepatitis. The extensive involvement of Rvbs in DNA-associated processes, including their interaction with a wide range of transcription factors, suggests that Rvb dysregulation may be involved in a number of other pathological processes yet to be elucidated. The IMG-6594A antibody recognizes Rvb1. Rvb1 is also known as Rubvl1, ECP54, TIP49, NMP238, TIP49A, LOC8607, RuvB-like 1, RuvB (E coli homolog)-like 1, and TATA binding protein interacting protein 49 kDa.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt, Ca, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Dr
Applications: WB, Simple Western, ChIP, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu
Applications: WB, Simple Western, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP, IHC-FrFl
Species: Hu
Applications: WB, IP
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, S-ELISA
Species: Hu, Mu, Rt, Ch, Pm
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, PEP-ELISA
Species: Hu, Mu, Rt
Applications: WB
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Ca
Applications: IP (-), WB, Simple Western, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: IP (-), WB, Simple Western, ICC/IF, IHC, IHC-P, PLA
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, IHC, IHC-P, S-ELISA
Species: Hu
Applications: WB
Supplier Logo

Publications for RUVBL1 Antibody (NBP2-27148) (0)

There are no publications for RUVBL1 Antibody (NBP2-27148).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for RUVBL1 Antibody (NBP2-27148) (0)

There are no reviews for RUVBL1 Antibody (NBP2-27148). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for RUVBL1 Antibody (NBP2-27148) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional RUVBL1 Antibody Products

Related Products by Gene

Bioinformatics Tool for RUVBL1 Antibody (NBP2-27148)

Discover related pathways, diseases and genes to RUVBL1 Antibody (NBP2-27148). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for RUVBL1 Antibody (NBP2-27148)

Discover more about diseases related to RUVBL1 Antibody (NBP2-27148).

Pathways for RUVBL1 Antibody (NBP2-27148)

View related products by pathway.

PTMs for RUVBL1 Antibody (NBP2-27148)

Learn more about PTMs related to RUVBL1 Antibody (NBP2-27148).

Research Areas for RUVBL1 Antibody (NBP2-27148)

Find related products by research area.

Blogs on RUVBL1

There are no specific blogs for RUVBL1, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol RUVBL1

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NBP2-27148 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought