Recombinant Human RSK2 Protein

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HPLC: Recombinant RSK2 Protein [NBP1-99502]

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.1 mg/ml

Order Details

Recombinant Human RSK2 Protein Summary

Description
Recombinant protein for Human RSK2

Source:Baculovirus (Sf9 insect cells)
Amino Acid Sequence:(NM_004586)

Source
Sf 9 (baculovirus)
Protein/Peptide Type
Biologically Active Protein
Gene
RPS6KA3
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Application Notes
Specific activity: The specific activity of RSK2 was determined to be 157 nmol /min/mg as per activity assay protocol.
Theoretical MW
112 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
Concentration
0.1 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human RSK2 Protein

  • 90 kDa ribosomal protein S6 kinase 3
  • CLS
  • Coffin-Lowry syndrome
  • EC 2.7.11
  • EC 2.7.11.1
  • HU-3
  • Insulin-stimulated protein kinase 1
  • ISPK1
  • ISPK-1
  • MAP kinase-activated protein kinase 1b
  • MAPK-activated protein kinase 1b
  • MAPKAP kinase 1b
  • MAPKAPK1B
  • MAPKAPK-1b
  • mental retardation, X-linked 19
  • MRX19
  • p90-RSK2
  • p90RSK3
  • pp90RSK2
  • ribosomal protein S6 kinase alpha-3
  • ribosomal protein S6 kinase, 90kD, polypeptide 3
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3
  • Ribosomal S6 kinase 2
  • RPS6KA3
  • RSK
  • RSK2
  • RSK-2
  • RSK2p90-RSK 3
  • S6K-alpha3
  • S6K-alpha-3

Background

RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Bioinformatics

Gene Symbol RPS6KA3
Entrez