ROR alpha/NR1F1 Antibody

Western Blot: ROR alpha/NR1F1 Antibody [NBP2-24519] - Analysis of ROR alpha in human skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse skeletal muscle lysate and 4) rat skeletal muscle lysate using this antibody at 25 ug/ml, 0.01 ug/ml and 0.01 ug/ml, respectively.

Product Discontinued

ROR alpha/NR1F1 Antibody Summary

• Immunogen: A portion of amino acids 80-120 of human ROR alpha was used as the immunogen.
• Predicted Species: Monkey (100%), Zebrafish (100%), Opossum (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RORA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.01-0.25 ug/ml

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (86%), Chimpanzee (80%) and Xenopus (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ROR alpha/NR1F1 Antibody

• DKFZp686M2414
• MGC119326
• NR1F1
• NR1F1MGC119329
• nuclear receptor ROR-alpha
• Nuclear receptor RZR-alpha
• Nuclear receptor subfamily 1 group F member 1
• RAR-related orphan receptor A
• RAR-related orphan receptor alpha
• retinoic acid receptor-related orphan receptor alpha
• retinoid-related orphan receptor alpha
• Retinoid-related orphan receptor-alpha
• ROR alpha
• ROR1
• ROR2
• ROR3
• RORA
• RZRA
• RZR-ALPHA
• RZRAROR-alpha
• transcription factor RZR-alpha

Background

Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. To date, ROR alpha, beta, and gamma subtypes have been discovered. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ROR alpha/NR1F1 Antibody (NBP2-24519)(1)

Publication using NBP2-24519

• Ding M, Lu Y, Huang X et al. Acute hypoxia induced dysregulation of clock-controlled ovary functions Frontiers in Physiology 2022-12-23 [PMID: 36620217] (WB, Mouse)

Bioinformatics

• Gene Symbol: RORA
• Uniprot:
  • P35398()