RGS2 Antibody - BSA Free

Western Blot: RGS2 Antibody [NB100-56736] - Western bot analysis of RGS2 in human heart lysate using RGS2 antibody at 2 ug/ml.

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.5 mg/ml

RGS2 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit RGS2 Antibody - BSA Free (NB100-56736) is a polyclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A synthetic peptide within amino acid residues 1-50 of human RGS2 was used as immunogen.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RGS2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1 - 3 ug/ml

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: mouse (86%) and rat (86%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, 0.2% gelatin
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for RGS2 Antibody - BSA Free

• Cell growth-inhibiting gene 31 protein
• G0 to G1 switch regulatory 8, 24kD
• G0/G1 switch regulatory protein 8
• G0S8cell growth-inhibiting protein 31
• regulator of G-protein signaling 2
• regulator of G-protein signaling 2, 24kDa
• regulator of G-protein signalling 2, 24kD
• regulator of G-protein signalling 2, 24kDa

Background

RGSs are a protein family containing a conserved 120 amino acid domain (RGS domain), which bind directly to activated G-alpha subunits (Gai and Gaq) and act as GTPase-activating proteins (GAPs). RGS2 is expressed in thyroid, heart. thyroid, and monocyte-derived DCs. The function of RGS2 as a regulator of Gq is also dependent on regulatory sequences in its amino-terminal domain that direct its localization to the plasma membrane. Recent studies have shown that RGS2 is critical for blood pressure homeostasis, and has been suggested to serve as an effector of the NO-cGMP pathway that promotes vascular relaxation based on studies of aortic rings in vitro.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RGS2
• Entrez:
  • 5997(Human)
  • 19735(Mouse)
  • 84583(Rat)
• Uniprot:
  • P41220(Human)