Retinol Binding Protein RBP Antibody (rRBP1/872) [Janelia Fluor® 585]

Product Discontinued

Retinol Binding Protein RBP Antibody (rRBP1/872) [Janelia Fluor® 585] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant full-length human Retinol Binding Protein RBP protein
• Epitope: aa 74-182
• Localization: Cytoplasmic
• Specificity: This monoclonal antibody recognizes an epitope within the 74-182 C-terminal sequence (11kD peptide fragment) of human serum Cellular Retinol Binding Protein 1 (CRBP 1), a single-chain glycoprotein belonging to the superfamily of hydrophobic molecule transporter proteins, which is responsible for transport of retinol (vitamin A1) from the liver to peripheral target tissues, like the eye, where it mediates the cellular uptake. CRBP 1 is synthesized by hepatic parenchymal cells where it becomes bound to its ligand retinol and is then released into the circulation, where it binds further to the protein transthyretin, to form a transporting complex, which is big enough not to be lost by filtration through the kidney glomeruli. It is detected in nearly all tissues with higher expression in adult ovary, pancreas, pituitary gland, adrenal gland, and fetal liver.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: RBP1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Retinol Binding Protein RBP Antibody (rRBP1/872) [Janelia Fluor® 585]

• C
• Cellular retinol-binding protein
• CRABP-I
• CRBP1CRBP-I
• CRBPCellular retinol-binding protein I
• CRBPI
• RBPC
• retinol binding protein 1, cellular
• retinol-binding protein 1
• retinol-binding protein 1, cellular

Background

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RBP1