Recombinant Mouse SCF Protein

1 μg/lane of Recombinant Mouse SCF/c-kit was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

Recombinant Mouse SCF/c-kit Ligand (Catalog # 455-MC) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 2.5-10 ng/mL.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse SCF Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 2.5-10 ng/mL.
• Source: E. coli-derived mouse SCF/c-kit Ligand protein
  Lys26-Ala189, with an N-terminal Met
• Accession #: Q78ED8
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Kitl
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 18.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse SCF Protein

• c-kit Ligand
• DCUA
• DFNA69
• DKFZp686F2250
• familial progressive hyperpigmentation 2
• FPH2
• FPHH
• KIT ligand
• Kitl
• KITLG
• KL-1
• Mast cell growth factor
• MGF
• MGFSHEP7
• SCF
• SCFStem cell factor
• SFc-Kit ligand
• SHEP7
• SLF
• steel factor

Background

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein (1). It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1 - 7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). Mature mouse SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail (9). The ECD shows both N-linked and O-linked glycosylation (10). Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice (11, 12). An alternately spliced isoform of mouse SCF lacks 28 aa that encompasses the primary proteolytic recognition site (13). Within the ECD of the short isoform (corresponding to this recombinant protein), mouse SCF shares 93% aa sequence identity with rat SCF and 72% - 75% with canine, feline, and human SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (14). Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling (15). SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (16).

1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037.
2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599. 
3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1.
4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201. 
5. Kapur, R. et al. (2002) Blood 100:1287.
6. Wang, C.-H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540.
7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 
8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327. 
9. Huang, E. et al. (1990) Cell 63:225.
10. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942.
11. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237.
12. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671.
13. Flanagan, J.G. et al. (1991) Cell 64:1025.
14. Martin, F.H. et al. (1990) Cell 63:203.
15. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311.
16. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117.

Publications for SCF/c-kit Ligand (455-MC)(163)

Publications using 455-MC

• R Deshycka, V Sudaryo, NJ Huang, Y Xie, LY Smeding, MK Choi, HL Ploegh, HF Lodish, N Pishesha Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity PLoS ONE, 2021;16(11):e0259353. 2021 [PMID: 34731223] (Bioassay, Mouse)
• T Kobayashi, A Castillo-V, CA Penfold, M Morgan, N Mizuno, WWC Tang, Y Osada, M Hirao, F Yoshida, H Sato, H Nakauchi, M Hirabayash, MA Surani Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells Cell Reports, 2021;37(2):109812. 2021 [PMID: 34644585] (Bioassay, Rabbit)
• HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 2021;7(41):eabg4167. 2021 [PMID: 34623912] (Bioassay, Mouse)
• SR Naidu, M Capitano, J Ropa, S Cooper, X Huang, HE Broxmeyer Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects Leukemia, 2021;0(0):. 2021 [PMID: 34599272] (Bioassay, Mouse)
• Y Ishikura, H Ohta, T Sato, Y Murase, Y Yabuta, Y Kojima, C Yamashiro, T Nakamura, T Yamamoto, T Ogawa, M Saitou In�vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells Cell Stem Cell, 2021;0(0):. 2021 [PMID: 34496297] (Bioassay, Mouse)
• C Zhao, Y Zhao, J Zhao, G Meng, S Huang, Y Liu, S Wang, L Qi Acute myeloid leukemia cell-derived extracellular vesicles carrying microRNA-548ac regulate hematopoietic function via the TRIM28/STAT3 pathway Cancer Gene Therapy, 2021;0(0):. 2021 [PMID: 34453123] (Bioassay, Mouse)
• K Yamamoto, S Goyama, S Asada, T Fujino, T Yonezawa, N Sato, R Takeda, A Tsuchiya, T Fukuyama, Y Tanaka, A Yokoyama, H Toya, A Kon, Y Nannya, R Onoguchi-M, S Nakagawa, T Hirose, S Ogawa, N Akimitsu, T Kitamura A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells Cell Reports, 2021;36(8):109576. 2021 [PMID: 34433054] (Bioassay, Mouse)
• N Ohashi, T Terashima, M Katagi, Y Nakae, J Okano, Y Suzuki, H Kojima GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS Scientific Reports, 2021;11(1):12803. 2021 [PMID: 34140581] (Cell Culture, Mouse)
• F Herbst, TJL Lang, ESP Eckert, P Wünsche, AA Wurm, T Kindinger, K Laaber, S Hemmati, A Hotz-Wagen, O Zavidij, A Paruzynski, J Lu, C von Kalle, T Zenz, C Klein, M Schmidt, CR Ball, H Glimm The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision Leukemia, 2021;0(0):. 2021 [PMID: 34021250] (Bioassay, Mouse)
• RA Cardenas, R Gonzalez, E Sanchez, MA Ramos, EI Cardenas, AI Rodarte, RJ Alcazar-Fe, A Isaza, AR Burns, R Heidelberg, R Adachi SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis The Journal of Biological Chemistry, 2021;296(0):100268. 2021 [PMID: 33837726] (Cell Culture, Mouse)
• J Lu, S Li, X Li, W Zhao, X Duan, X Gu, J Xu, B Yu, LJ Sigal, Z Dong, L Xie, M Fang Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging Aging Cell, 2021;0(0):e13353. 2021 [PMID: 33780118] (Bioassay, Mouse)
• AK Persaud, S Nair, MF Rahman, R Raj, B Weadick, D Nayak, C McElroy, M Shanmugam, S Knoblaugh, X Cheng, R Govindaraj Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors Nature Communications, 2021;12(1):1248. 2021 [PMID: 33623001] (Bioassay)
• S Takashima, S Usui, O Inoue, C Goten, K Yamaguchi, Y Takeda, S Cui, Y Sakai, K Hayashi, K Sakata, MA Kawashiri, M Takamura Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells Scientific Reports, 2021;11(1):1520. 2021 [PMID: 33452355] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020;33(13):108553. 2020 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• Y Hong, N Singh, S Bamopoulos, E Gjerga, LK Schmalbroc, K Balabanian, M Schick, U Keller, M Wirth Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System Biomedicines, 2020;8(12):. 2020 [PMID: 33317212] (Bioassay, Mouse)
• T Trinh, J Ropa, A Aljoufi, S Cooper, A Sinn, EF Srour, HE Broxmeyer Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells Leukemia, 2020;0(0):. 2020 [PMID: 33159180] (Cell Culture, Mouse)
• M Girotra, V Trachsel, A Roch, MP Lutolf In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro Int J Mol Sci, 2020;21(21):. 2020 [PMID: 33153113] (Cell Culture, Mouse)
• M Wada, Y Shimada, S Iizuka, N Ishii, H Hiraki, T Tachibana, K Maeda, M Saito, S Arakawa, T Ishimoto, T Nakano, H Ida, T Ohashi, H Kobayashi Ex�Vivo Gene Therapy Treats Bone Complications of Mucopolysaccharidosis Type II Mouse Models through Bone Remodeling Reactivation Mol Ther Methods Clin Dev, 2020;19(0):261-274. 2020 [PMID: 33102618] (Bioassay, Mouse)
• H Huang, CA Howard, S Zari, HJ Cho, S Shukla, H Li, J Ndoj, P González-A, C Nikolaidis, J Abbott, DS Rogawski, MA Potopnyk, K Kempinska, H Miao, T Purohit, A Henderson, A Mapp, ML Sulis, A Ferrando, J Grembecka, T Cierpicki Covalent inhibition of NSD1 histone methyltransferase Nat. Chem. Biol., 2020;0(0):. 2020 [PMID: 32868895] (Bioassay, Mouse)
• V Peng, C Georgescu, A Bakowska, A Pankow, L Qian, JD Wren, XH Sun E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 2020;0(0):. 2020 [PMID: 32817168] (Cell Culture, Mouse)
• C Cho, R Mukherjee, AR Peck, Y Sun, N McBrearty, KV Katlinski, J Gui, PK Govindaraj, E Puré, H Rui, SY Fuchs Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis Oncogene, 2020;0(0):. 2020 [PMID: 32807917] (Bioassay, Mouse)
• NV Bogert, J Furkel, S Din, I Braren, V Eckstein, JA Müller, L Uhlmann, HA Katus, MH Konstandin A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus Sci Rep, 2020;10(1):13740. 2020 [PMID: 32792615] (Bioassay, Mouse)
• L Garcia-Per, M van Eggerm, L van Roon, SA Vloemans, M Cordes, A Schambach, M Rothe, D Berghuis, C Lagresle-P, M Cavazzana, F Zhang, AJ Thrasher, D Salvatori, P Meij, A Villa, JJM Van Dongen, JJ Zwaginga, M van der Bu, HB Gaspar, A Lankester, FJT Staal, K Pike-Overz Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID Mol Ther Methods Clin Dev, 2020;17(0):666-682. 2020 [PMID: 32322605] (Bioassay, Mouse)
• C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou Generation of human oogonia from induced pluripotent stem cells in culture Nat Protoc, 2020;15(4):1560-1583. 2020 [PMID: 32231324] (Bioassay, Human)
• S Kreutmair, C Klingeberg, T Poggio, G Andrieux, A Keller, C Miething, M Follo, D Pfeifer, K Shoumariye, C Lengerke, I Gonzalez-M, F Fend, R Zeiser, SD Turner, L Quintanill, M Boerries, J Duyster, AL Illert Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model Leukemia, 2020;0(0):. 2020 [PMID: 32203142] (Cell Culture, Mouse)
• A Yoshimi, TM Trippett, N Zhang, X Chen, AV Penson, ME Arcila, J Pichardo, J Baik, A Sigler, H Harada, DC Fajgenbaum, A Dogan, O Abdel-Waha, W Xiao Genetic basis for iMCD-TAFRO Oncogene, 2020;0(0):. 2020 [PMID: 32051554] (Bioassay, Mouse)
• JM Bertho, D Kereselidz, L Manens, C Culeux, V Magneron, J Surette, M Blimkie, L Bertrand, H Wyatt, M Souidi, I Dublineau, N Priest, JR Jourdain Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism Sci Rep, 2019;9(1):19919. 2019 [PMID: 31882739] (Multiplex Standard, Mouse)
• T Fukushima, Y Tanaka, FK Hamey, CH Chang, T Oki, S Asada, Y Hayashi, T Fujino, T Yonezawa, R Takeda, KC Kawabata, T Fukuyama, T Umemoto, K Takubo, H Takizawa, S Goyama, Y Ishihama, H Honda, B Göttgens, T Kitamura Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium Cell Rep, 2019;29(12):4144-4158.e7. 2019 [PMID: 31851939] (Cell Culture, Mouse)
• R Magadmi, J Meszaros, ZA Damanhouri, EP Seward Secretion of Mast Cell Inflammatory Mediators Is Enhanced by CADM1-Dependent Adhesion to Sensory Neurons Front Cell Neurosci, 2019;13(0):262. 2019 [PMID: 31275114] (Bioassay, Mouse)
• S Nair, AM Strohecker, AK Persaud, B Bissa, S Muruganand, C McElroy, R Pathak, M Williams, R Raj, A Kaddoumi, A Sparreboom, AM Beedle, R Govindaraj Adult stem cell deficits drive Slc29a3 disorders in mice Nat Commun, 2019;10(1):2943. 2019 [PMID: 31270333] (Cell Culture, Mouse)
• XU Haiqian, W Li, S Luo, J Yuan, L Hao Adipose derived stem cells promote tumor metastasis in breast Cancer cells by stem cell factor inhibition of miR20b Cell. Signal., 2019;62(0):109350. 2019 [PMID: 31254605] (Bioassay, Mouse)
• ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 2019;130(0):2555-2570. 2019 [PMID: 31107242] (Bioassay, Human)
• YL Chang, Z Wang, S Igawa, JE Choi, T Werbel, A Di Nardo Lipocalin 2: A New Antimicrobial in Mast Cells Int J Mol Sci, 2019;20(10):. 2019 [PMID: 31091692] (Cell Culture, Mouse)
• SK Nandakumar, SK McFarland, LM Mateyka, CA Lareau, JC Ulirsch, LS Ludwig, G Agarwal, JM Engreitz, B Przychodze, M McConkey, GS Cowley, JG Doench, JP Maciejewsk, BL Ebert, DE Root, VG Sankaran Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis Elife, 2019;8(0):. 2019 [PMID: 31070582] (Bioassay, Mouse)
• MJ Delás, BT Jackson, T Kovacevic, S Vangelisti, E Munera Mar, SA Wild, EM Stork, N Erard, SRV Knott, GJ Hannon lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation Cell Rep, 2019;27(3):719-729.e6. 2019 [PMID: 30995471] (cell culture media, Mouse)
• S Mayers, PD Moço, T Maqbool, PN Silva, DM Kilkenny, J Audet Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector BMC Biotechnol., 2019;19(1):21. 2019 [PMID: 30987611] (Bioassay, Mouse)
• C Li, L Dong, R Su, Y Bi, Y Qing, X Deng, Y Zhou, C Hu, M Yu, H Huang, X Jiang, X Li, X He, D Zou, C Shen, L Han, M Sun, J Skibbe, K Ferchen, X Qin, H Weng, H Huang, C Song, J Chen, J Jin Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC Haematologica, 2019;0(0):. 2019 [PMID: 30975912] (Bioassay, Mouse)
• N Vannini, V Campos, M Girotra, V Trachsel, S Rojas-Sutt, J Tratwal, S Ragusa, E Stefanidis, D Ryu, PY Rainer, G Nikitin, S Giger, TY Li, A Semilietof, A Oggier, Y Yersin, L Tauzin, E Pirinen, WC Cheng, J Ratajczak, C Canto, M Ehrbar, F Sizzano, TV Petrova, D Vanhecke, L Zhang, P Romero, A Nahimana, S Cherix, MA Duchosal, PC Ho, B Deplancke, G Coukos, J Auwerx, MP Lutolf, O Naveiras The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance Cell Stem Cell, 2019;24(3):405-418.e7. 2019 [PMID: 30849366] (Bioassay, Mouse)
• AD Senft, EK Bikoff, EJ Robertson, I Costello Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse Nat Commun, 2019;10(1):1089. 2019 [PMID: 30842446] (Bioassay, Mouse)
• N Maio, KS Kim, G Holmes-Ham, A Singh, TA Rouault Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis Haematologica, 2019;0(0):. 2019 [PMID: 30765471] (Bioassay, Mouse)
• JE Choi, T Werbel, Z Wang, CC Wu, TL Yaksh, A Di Nardo Botulinum toxin blocks mast cells and prevents rosacea like inflammation J. Dermatol. Sci., 2018;0(0):. 2018 [PMID: 30658871] (Bioassay, Mouse)
• F Ribezzo, IAM Snoeren, S Ziegler, J Stoelben, PA Olofsen, A Henic, MV Ferreira, S Chen, USA Stalmann, G Buesche, RM Hoogenboez, R Kramann, U Platzbecke, MHGP Raaijmaker, BL Ebert, RK Schneider Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome Leukemia, 2019;0(0):. 2019 [PMID: 30651631] (Bioassay, Mouse)
• W Fonseca, AJ Rasky, C Ptaschinsk, SH Morris, SKK Best, M Phillips, CA Malinczak, NW Lukacs Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease Mucosal Immunol, 2019;12(2):445-456. 2019 [PMID: 30617299]
• E Sanchez, EA Gonzalez, DS Moreno, RA Cardenas, MA Ramos, AJ Davalos, J Manllo, AI Rodarte, Y Petrova, DC Moreira, MA Chavez, A Tortoriell, A Lara, BA Gutierrez, AR Burns, R Heidelberg, R Adachi Syntaxin 3, but not Syntaxin 4, is required for mast cell regulated exocytosis, where it plays a primary role mediating compound exocytosis J. Biol. Chem., 2018;0(0):. 2018 [PMID: 30563839] (Bioassay, Mouse)
• Z He, J Song, J Hua, M Yang, Y Ma, T Yu, J Feng, B Liu, X Wang, Y Li, J Li Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons Cell Death Dis, 2018;9(12):1173. 2018 [PMID: 30518915] (Bioassay, Mouse)
• Y Kimizuka, W Katagiri, JJ Locascio, A Shigeta, Y Sasaki, M Shibata, K Morse, RF Sîrbulescu, M Miyatake, P Reeves, M Suematsu, J Gelfand, T Brauns, MC Poznansky, K Tsukada, S Kashiwagi Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response J. Immunol., 2018;0(0):. 2018 [PMID: 30420435] (Cell Culture, Mouse)
• AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming Cell Rep, 2018;24(8):1977-1985.e7. 2018 [PMID: 30134160] (Bioassay, Mouse)
• SK Sweeney, GS Manzar, N Zavazava, JG Assouline Tracking embryonic hematopoietic stem cells to the bone marrow: nanoparticle options to evaluate transplantation efficiency Stem Cell Res Ther, 2018;9(1):204. 2018 [PMID: 30053892] (Bioassay, Mouse)
• Y Heshmati, S Kharazi, G Türköz, D Chang, E Kamali Dol, J Boström, A Krstic, T Boukoura, E Wagner, N Kadri, R Månsson, M Altun, H Qian, J Walfridsso The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation Sci Rep, 2018;8(1):11202. 2018 [PMID: 30046127] (Bioassay, Mouse)
• H Tokuo, J Bhawan, LM Coluccio Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis Sci Rep, 2018;8(1):10449. 2018 [PMID: 29993000] (Bioassay, Mouse)
• P Wünsche, ESP Eckert, T Holland-Le, A Paruzynski, A Hotz-Wagen, R Fronza, T Rath, I Gil-Farina, M Schmidt, C von Kalle, C Klein, CR Ball, F Herbst, H Glimm Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs Cell Stem Cell, 2018;23(1):132-146.e9. 2018 [PMID: 29979988] (Bioassay, Mouse)
• X Jin, X He, X Cao, P Xu, Y Xing, S Sui, L Wang, J Meng, W Lu, R Cui, H Ni, M Zhao Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice Haematologica, 2018;0(0):. 2018 [PMID: 29903757] (In Vivo, Mouse)
• SK Tasian, JA Casas, D Posocco, S Gandre-Bab, AL Gagne, G Liang, ML Loh, MJ Weiss, DL French, ST Chou Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells Leukemia, 2018;0(0):. 2018 [PMID: 29884903] (Bioassay, Mouse)
• JP Sasine, HA Himburg, CM Termini, M Roos, E Tran, L Zhao, J Kan, M Li, Y Zhang, SC de Barros, DS Rao, CM Counter, JP Chute Wild-type Kras expands and exhausts hematopoietic stem cells JCI Insight, 2018;3(11):. 2018 [PMID: 29875320] (Bioassay, Mouse)
• JP Sasine, HA Himburg, CM Termini, M Roos, E Tran, L Zhao, J Kan, M Li, Y Zhang, SC de Barros, DS Rao, CM Counter, JP Chute Wild-type Kras expands and exhausts hematopoietic stem cells JCI Insight, 2018;3(11):. 2018 [PMID: 29875320] (Bioassay, Mouse)
• M Reitz, W Hartmann, N Rüdiger, Z Orinska, ML Brunn, M Breloer Interleukin-9 promotes early mast cell-mediated expulsion of Strongyloides ratti but is dispensable for generation of protective memory Sci Rep, 2018;8(1):8636. 2018 [PMID: 29872093] (Bioassay, Mouse)
• A Rasheed, R Tsai, CL Cummins Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells J Am Heart Assoc, 2018;7(10):. 2018 [PMID: 29739800] (Bioassay, Mouse)
• HT Fang, CA El Farran, QR Xing, LF Zhang, H Li, B Lim, YH Loh Global H3.3 dynamic deposition defines its bimodal role in cell fate transition Nat Commun, 2018;9(1):1537. 2018 [PMID: 29670118] (Bioassay, Mouse)
• C Sahin, R Mamillapal, HS Taylor Bone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury Reprod Sci, 2018;0(0):1933719118770. 2018 [PMID: 29658434] (In Vivo, Mouse)
• R Nagase, D Inoue, A Pastore, T Fujino, HA Hou, N Yamasaki, S Goyama, M Saika, A Kanai, Y Sera, S Horikawa, Y Ota, S Asada, Y Hayashi, KC Kawabata, R Takeda, HF Tien, H Honda, O Abdel-Waha, T Kitamura Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation J. Exp. Med., 2018;0(0):. 2018 [PMID: 29643185] (Bioassay, Mouse)
• BA Gutierrez, MA Chavez, AI Rodarte, M Ramos, A Dominguez, Y Petrova, AJ Davalos, RM Costa, R Elizondo, MJ Tuvim, BF Dickey, AR Burns, R Heidelberg, R Adachi Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle regulated exocytosis in mast cells J. Biol. Chem., 2018;0(0):. 2018 [PMID: 29599294] (Bioassay, Mouse)
• JS Dahlin, FK Hamey, B Pijuan-Sal, M Shepherd, WWY Lau, S Nestorowa, C Weinreb, S Wolock, R Hannah, E Diamanti, DG Kent, B Göttgens, NK Wilson A single cell hematopoietic landscape resolves eight lineage trajectories and defects in Kit mutant mice Blood, 2018;0(0):. 2018 [PMID: 29588278] (Bioassay, Mouse)
• R Ramachandr, MJ Marino, S Paul, Z Wang, NL Mascarenha, S Pellett, EA Johnson, A DiNardo, TL Yaksh A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus Toxins (Basel), 2018;10(4):. 2018 [PMID: 29570628] (Differentiation, Mouse)
• MA Cherian, S Olson, H Sundaramoo, K Cates, X Cheng, J Harding, A Martens, GA Challen, M Tyagi, L Ratner, D Rauch An activating mutation of interferon regulatory factor 4 (IRF4) in adult T cell leukemia J. Biol. Chem., 2018;0(0):. 2018 [PMID: 29540473] (Bioassay, Mouse)
• YY Wang, S Ma, Q Chen, D Jiao, Y Yang In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87Amutant in hematopoietic stem cell-transplanted mice Gene Ther., 2018;0(0):. 2018 [PMID: 29523881] (Bioassay, Mouse)
• H Wang, L Bei, CA Shah, W Huang, LC Platanias, EA Eklund The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia Oncogene, 2018;0(0):. 2018 [PMID: 29459712] (Bioassay, Mouse)
• Q Cai, M Capitano, X Huang, B Guo, S Cooper, HE Broxmeyer Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air Blood Cells Mol. Dis., 2018;0(0):. 2018 [PMID: 29422232] (Bioassay, Mouse)
• M Bachmann, M Vogel, L Zha, F Leoratti, L He, MO Mohsen, F Storni, M Cragg, An unexpected protective role of low affinity allergen-specific IgG via the inhibitory receptor Fc?RIIb J. Allergy Clin. Immunol., 2018;0(0):. 2018 [PMID: 29391255] (Cell Culture, Mouse)
• K Dai, Y Huang, Z Chen, X Sun, L Yang, Y Jiang Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model Eur. J. Immunol., 2018;0(0):. 2018 [PMID: 29331106] (Bioassay, Mouse)
• X Jiang, C Hu, K Ferchen, J Nie, X Cui, CH Chen, L Cheng, Z Zuo, W Seibel, C He, Y Tang, JR Skibbe, M Wunderlich, WC Reinhold, L Dong, C Shen, S Arnovitz, B Ulrich, J Lu, H Weng, R Su, H Huang, Y Wang, C Li, X Qin, J Mulloy, Y Zheng, J Diao, J Jin, C Li, PP Liu, C He, Y Chen, J Chen Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia Nat Commun, 2017;8(1):2099. 2017 [PMID: 29235481] (Bioassay, Mouse)
• NJ Huang, N Pishesha, J Mukherjee, S Zhang, R Deshycka, V Sudaryo, M Dong, CB Shoemaker, HF Lodish Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin Nat Commun, 2017;8(1):423. 2017 [PMID: 28871080] (Bioassay, Mouse)
• D Sainz de l, A Moratilla, V Aparicio, C Lorca, Y Alcaina, D Martín, MP De Miguel Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency Oxid Med Cell Longev, 2017;2017(0):4745252. 2017 [PMID: 28757909] (Bioassay, Mouse)
• T Maetzig, J Ruschmann, L Sanchez Mi, CK Lai, N von Krosig, RK Humphries Lentiviral Fluorescent Genetic Barcoding for Multiplex Fate Tracking of Leukemic Cells Mol Ther Methods Clin Dev, 2017;6(0):54-65. 2017 [PMID: 28664166] (Bioassay, Mouse)
• Q Bernard, Z Wang, A Di Nardo, N Boulanger Interaction of primary mast cells with Borrelia burgdorferi (sensu stricto): role in transmission and dissemination in C57BL/6 mice Parasit Vectors, 2017;10(1):313. 2017 [PMID: 28655322] (Bioassay, Mouse)
• Y Chen, K Anastassia, A Kranz, AF Stewart, K Arndt, C Waskow, A Yokoyama, K Jones, T Neff, Y Lee, P Ernst MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia Cancer Cell, 2017;31(6):755-770.e6. 2017 [PMID: 28609655] (Bioassay, Mouse)
• J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease Mol Ther Methods Clin Dev, 2017;5(0):241-258. 2017 [PMID: 28603745] (Bioassay, Mouse)
• H Ohta, K Kurimoto, I Okamoto, T Nakamura, Y Yabuta, H Miyauchi, T Yamamoto, Y Okuno, M Hagiwara, K Shirane, H Sasaki, M Saitou In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate EMBO J., 2017;0(0):. 2017 [PMID: 28559416] (Bioassay, Mouse)
• Y Zhao, K Wu, C Nguyen, G Smbatyan, E Melendez, Y Higuchi, Y Chen, M Kahn Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation PLoS ONE, 2017;12(5):e0177245. 2017 [PMID: 28486541] (Bioassay, Mouse)
• S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017;14(5):531-538. 2017 [PMID: 28394335] (Bioassay, Mouse)
• A Itoh-Nakad, M Matsumoto, H Kato, J Sasaki, Y Uehara, Y Sato, R Ebina-Shib, M Morooka, R Funayama, K Nakayama, K Ochiai, A Muto, K Igarashi A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors Cell Rep, 2017;18(10):2401-2414. 2017 [PMID: 28273455] (Bioassay, Mouse)
• B Guo, X Huang, S Cooper, HE Broxmeyer Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment Nat. Med, 2017;0(0):. 2017 [PMID: 28263313] (Bioassay, Mouse)
• JL Weaver, S Arandjelov, G Brown, S K Mendu, M S Schappe, MW Buckley, YH Chiu, S Shu, JK Kim, J Chung, J Krupa, V Jevtovic-T, BN Desai, KS Ravichandr, DA Bayliss Hematopoietic pannexin 1 function is critical for neuropathic pain Sci Rep, 2017;7(0):42550. 2017 [PMID: 28195232] (Bioassay, Mouse)
• AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich Anti-KIT Monoclonal Antibody Treatment Enhances the Anti-Tumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression Mol. Cancer Ther, 2017;0(0):. 2017 [PMID: 28138031] (Bioassay, Mouse)
• Y Han, L Yue, M Wei, X Ren, Z Shao, L Zhang, RL Levine, PK Epling-Bur Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis PLoS ONE, 2017;12(1):e0166014. 2017 [PMID: 28135282] (Bioassay, Mouse)
• KZ Oben, BW Gachuki, SS Alhakeem, MK McKenna, Y Liang, DK St Clair, VM Rangnekar, S Bondada Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1) PLoS ONE, 2017;12(1):e0169767. 2017 [PMID: 28081176] (Bioassay, Mouse)
• In�Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells Cell Rep, 2016;17(10):2789-2804. 2016 [PMID: 27926879] (Bioassay, Mouse)
• Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms Nat. Med, 2016;0(0):. 2016 [PMID: 27918563] (Bioassay, Mouse)
• The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis Cell Death Dis, 2016;7(11):e2479. 2016 [PMID: 27882948] (Bioassay, Mouse)
• Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis Oncogene, 2016;0(0):. 2016 [PMID: 27869160] (Bioassay, Mouse)
• Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors Nat Commun, 2016;7(0):13396. 2016 [PMID: 27869129] (Bioassay, Mouse)
• Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2 Cancer Discov, 2016;0(0):. 2016 [PMID: 27630126] (Bioassay, Mouse)
• Arid3b Is Critical for B Lymphocyte Development PLoS ONE, 2016;11(8):e0161468. 2016 [PMID: 27537840] (Bioassay, Mouse)
• Systemic Ablation of MMP9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL-6 Expression in the Bone Marrow Mol Cancer Res, 2016;0(0):. 2016 [PMID: 27489361] (Bioassay, Mouse)
• Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency Stem Cell Reports, 2016;0(0):. 2016 [PMID: 27453007] (Bioassay, Mouse)
• Reprogramming M�ller glia via in vivo cell fusion regenerates murine photoreceptors J Clin Invest, 2016;0(0):. 2016 [PMID: 27427986] (Bioassay, Mouse)
• Franziska Ruf Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the in Vivo Regeneration of the Hematopoietic Stem Cell Pool Stem Cells, 2016;0(0):. 2016 [PMID: 27299503] (Bioassay, Mouse)
• Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis PLoS ONE, 2016;11(5):e0154630. 2016 [PMID: 27159398] (Bioassay, Mouse)
• Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins Nat. Med., 2016;22(6):672-8. 2016 [PMID: 27135740] (Bioassay, Mouse)
• X Jiang, C Hu, S Arnovitz, J Bugno, M Yu, Z Zuo, P Chen, H Huang, B Ulrich, S Gurbuxani, H Weng, J Strong, Y Wang, Y Li, J Salat, S Li, AG Elkahloun, Y Yang, MB Neilly, RA Larson, MM Le Beau, T Herold, SK Bohlander, PP Liu, J Zhang, Z Li, C He, J Jin, Hon miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia Nat Commun, 2016;7(0):11452. 2016 [PMID: 27116251] (Bioassay, Mouse)
• L Dimitrov, D Pedersen, KH Ching, H Yi, EJ Collarini, S Izquierdo, MC van de Lav, PA Leighton Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells PLoS ONE, 2016;11(4):e0154303. 2016 [PMID: 27099923] (Bioassay, Chicken)
• PA Leighton, D Pedersen, K Ching, EJ Collarini, S Izquierdo, R Jacob, MC van de Lav Generation of chickens expressing Cre recombinase Transgenic Res, 2016;0(0):. 2016 [PMID: 27034267] (Bioassay, Chicken)
• von Wnuck Lipinski K, Sattler K, Peters S, Weske S, Keul P, Klump H, Heusch G, Gothert J, Levkau B Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice. J Immunol, 2015;196(4):1655-65. 2015 [PMID: 26800876] (Bioassay, Mouse)
• Gonzalez Roldan N, Orinska Z, Ewers H, Bulfone-Paus S CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice. Eur J Immunol, 2015;46(2):432-9. 2015 [PMID: 26564814] (Bioassay, Mouse)
• O Iijima, K Miyake, A Watanabe, N Miyake, T Igarashi, C Kanokoda, A Nakamura-T, H Kinoshita, T Noguchi, S Abe, S Narisawa, JL Millán, T Okada, T Shimada Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells Hum. Gene Ther, 2015;26(12):801-12. 2015 [PMID: 26467745] (Bioassay, Mouse)
• Huan J, Hornick N, Goloviznina N, Kamimae-Lanning A, David L, Wilmarth P, Mori T, Chevillet J, Narla A, Roberts C, Loriaux M, Chang B, Kurre P Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes. Leukemia, 2015;29(12):2285-95. 2015 [PMID: 26108689] (Bioassay, Mouse)
• Liu D, Suchard S, Nadler S, Ford M Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression. PLoS ONE, 2015;10(6):e0130490. 2015 [PMID: 26098894] (Bioassay, Mouse)
• Sato T, Katagiri K, Kojima K, Komeya M, Yao M, Ogawa T In Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues. PLoS ONE, 2015;10(6):e0130171. 2015 [PMID: 26065832] (Bioassay, Mouse)
• Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg L, Stope M, Martincuks A, Vogt M, Gortz D, Camporeale A, Poli V, Muller-Newen G, Brummendorf T, Ziegler P Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol, 2015;8(0):64. 2015 [PMID: 26054961] (Bioassay, Mouse)
• Wang H, Bei L, Shah C, Hu L, Eklund E HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. J Immunol, 2015;194(11):5375-87. 2015 [PMID: 25895533] (Bioassay, Mouse)
• Kim P, Nakano H, Das P, Chen M, Rowe R, Chou S, Ross S, Sakamoto K, Zon L, Schlaeger T, Orkin S, Nakano A, Daley G Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med, 2015;212(5):633-48. 2015 [PMID: 25870201] (Bioassay, Mouse)
• Begonja A, Pluthero F, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo R, Nakamura F, Lehman W, Plomann M, Hoffmeister K, Kahr W, Hartwig J, Falet H FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood, 2015;126(1):80-8. 2015 [PMID: 25838348] (Bioassay, Mouse)
• Suzuki , Norio, Mukai , Harumi Y, Yamamoto , Masayuki In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. PLoS ONE, 2015;10(3):e0119442. 2015 [PMID: 25790231] (Bioassay, Mouse)
• Goldenson B, Kirsammer G, Stankiewicz M, Wen Q, Crispino J Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation. Blood, 2015;125(13):2141-50. 2015 [PMID: 25670627] (Bioassay, Mouse)
• Wang L, Rao T, Rowe R, Nguyen P, Sullivan J, Pearson D, Doulatov S, Wu L, Lindsley R, Zhu H, DeAngelo D, Daley G, Wagers A The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia, 2015;29(6):1320-30. 2015 [PMID: 25655194] (Bioassay, Mouse)
• Bando J, Liang H, Locksley R Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol, 2015;16(2):153-60. 2015 [PMID: 25501629] (Bioassay, Mouse)
• Bender M, Giannini S, Grozovsky R, Jonsson T, Christensen H, Pluthero F, Ko A, Mullally A, Kahr W, Hoffmeister K, Falet H Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood, 2015;125(6):1014-24. 2015 [PMID: 25468568] (Bioassay, Mouse)
• Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor. Stem Cells, 2015;33(3):976-87. 2015 [PMID: 25446279] (Bioassay, Mouse)
• Li B, Baylink D, Walter M, Lau K, Meng X, Wang J, Cherkas A, Tang X, Qin X Targeted 25-hydroxyvitamin D3 1alpha-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice. Mol Ther, 2015;23(2):339-51. 2015 [PMID: 25327179] (Bioassay, Mouse)
• Illert , A L, Albers , C, Kreutmair , S, Leischner , H, Peschel , C, Miething , C, Duyster , J Grb10 is involved in BCR-ABL-positive leukemia in mice. Leukemia, 2015;29(4):858-68. 2015 [PMID: 25249015] (Bioassay, Mouse)
• Luyten A, Zang C, Liu X, Shivdasani R Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev, 2014;28(16):1827-39. 2014 [PMID: 25128499] (Bioassay, Mouse)
• Liu X, Yuan H, Peres L, Chen S, Chen Z, de The H, Zhou J, Zhu J The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation. PLoS ONE, 2014;9(8):e104906. 2014 [PMID: 25119106] (Bioassay, Mouse)
• Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood, 2014;124(9):1393-403. 2014 [PMID: 24990886] (Bioassay, Mouse)
• Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer M, Zhang H, Hogquist K, Evavold B, Vignali D TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol, 2014;193(2):571-9. 2014 [PMID: 24943217] (Bioassay, Mouse)
• Hiragun T, Yanase Y, Okabe T, Hiragun M, Kawai M, Hide M Establishment of a mast cell line, NCL-2, without Kit mutation, derived from NC mouse bone marrow. FEBS Open Bio, 2014;4(0):342-6. 2014 [PMID: 24918047] (Bioassay, Mouse)
• Fukuda , S, Hoggatt , J, Singh , P, Abe , M, Speth , J M, Hu , P, Conway , E M, Nucifora , G, Yamaguchi , S, Pelus , L M Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. Leukemia, 2015;29(2):433-40. 2015 [PMID: 24903482] (Bioassay, Mouse)
• Patnode M, Bando J, Krummel M, Locksley R, Rosen S Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med, 2014;211(7):1281-8. 2014 [PMID: 24889202] (Bioassay, Mouse)
• Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata K, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood, 2014;123(25):3932-42. 2014 [PMID: 24825862] (Bioassay, Mouse)
• Nagareddy P, Kraakman M, Masters S, Stirzaker R, Gorman D, Grant R, Dragoljevic D, Hong E, Abdel-Latif A, Smyth S, Choi S, Korner J, Bornfeldt K, Fisher E, Dixit V, Tall A, Goldberg I, Murphy A Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab, 2014;19(5):821-35. 2014 [PMID: 24807222] (Bioassay, Mouse)
• Nam T, Park K, Shawl A, Kim B, Han M, Kim Y, Moss J, Kim U Critical role for NAD glycohydrolase in regulation of erythropoiesis by hematopoietic stem cells through control of intracellular NAD content. J Biol Chem, 2014;289(23):16362-73. 2014 [PMID: 24759100] (Bioassay, Rabbit)
• Park S, Umemoto T, Saito-Adachi M, Shiratsuchi Y, Yamato M, Nakai K Computational promoter modeling identifies the modes of transcriptional regulation in hematopoietic stem cells. PLoS ONE, 2014;9(4):e93853. 2014 [PMID: 24710559] (Bioassay, Mouse)
• Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res, 2014;74(10):2803-15. 2014 [PMID: 24686171] (Bioassay, Mouse)
• Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK. PLoS ONE, 2014;9(2):e89649. 2014 [PMID: 24586935] (Bioassay, Mouse)
• Chung , Jie-Yu, Figgett , William, Fairfax , Kirsten, Bernard , Claude, Chan , James, Toh , Ban-Hock, Mackay , Fabienne, Alderuccio , Frank Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion. J Immunol, 2014;192(6):2593-601. 2014 [PMID: 24532581] (Bioassay, Mouse)
• Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells. Immunology, 2014;142(3):421-30. 2014 [PMID: 24527810] (Bioassay, Mouse)
• Zimdahl , Bryan, Ito , Takahiro, Blevins , Allen, Bajaj , Jeevisha, Konuma , Takaaki, Weeks , Joi, Koechlein , Claire S, Kwon , Hyog You, Arami , Omead, Rizzieri , David, Broome , H Elizab, Chuah , Charles, Oehler , Vivian G, Sasik , Roman, Hardiman , Gary, Reya , Tannisht Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet, 2014;46(3):245-52. 2014 [PMID: 24487275] (Bioassay, Mouse)
• Reber L, Daubeuf F, Pejler G, Abrink M, Frossard N Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J Immunol, 2014;192(4):1847-54. 2014 [PMID: 24453258] (Bioassay, Mouse)
• Roderick , Justine, Tesell , Jessica, Shultz , Leonard, Brehm , Michael, Greiner , Dale L, Harris , Marian H, Silverman , Lewis B, Sallan , Stephen, Gutierrez , Alejandr, Look , A Thomas, Qi , Jun, Bradner , James E, Kelliher , Michelle c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood, 2014;123(7):1040-50. 2014 [PMID: 24394663] (Bioassay, Mouse)
• North , Matthew, Shuga , Joe, Fromowitz , Michele, Loguinov , Alexandr, Shannon , Kevin, Zhang , Luoping, Smith , Martyn T, Vulpe , Chris D Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer, 2014;14(0):6. 2014 [PMID: 24386979] (Bioassay, Mouse)
• Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports, 2013;1(6):545-59. 2013 [PMID: 24371809] (Bioassay, Mouse)
• Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells. Exp Cell Res, 2014;320(1):54-61. 2014 [PMID: 24080013] (Bioassay, Mouse)
• Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka I, Dyer M, Baron M Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells, 2014;32(1):191-203. 2014 [PMID: 24022884] (Bioassay, Mouse)
• Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, Clark N, Nomura-Kitabayashi A, Kovacic J, Ma'ayan A, Schaniel C, Lemischka I, Moore K Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell, 2013;13(2):205-18. 2013 [PMID: 23770078] (Bioassay, Mouse)
• Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol, 2013;43(4):979-88. 2013 [PMID: 23404570]
• Jeong H, Oh H, Nam S, Han N, Kim Y, Kim J, Lee S, Kim M, Moon P, Kim H, Oh H The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth. Int J Cancer, 2013;132(11):2492-501. 2013 [PMID: 23161568] (Bioassay, Mouse)
• Kinzfogl J, Hangoc G, Broxmeyer HE Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. Blood, 2011;118(3):565-75. 2011 [PMID: 21628410] (Bioassay, Mouse)
• Cook BD, Liu S, Evans T Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood, 2011;117(24):6489-97. 2011 [PMID: 21515822] (Bioassay, Mouse)
• Artus J, Panthier JJ, Hadjantonakis AK A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst. Development, 2010;137(20):3361-72. 2010 [PMID: 20826533] (Bioassay, Mouse)
• Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J. Immunol., 2009;183(2):925-36. 2009 [PMID: 19561101] (Bioassay, Mouse)
• Dolgachev VA, Ullenbruch MR, Lukacs NW, Phan SH Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling. Am. J. Pathol., 2009;174(2):390-400. 2009 [PMID: 19147822] (In Vivo, Mouse)
• Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood, 2008;112(9):3878-88. 2008 [PMID: 18694996] (Bioassay, Mouse)
• Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells, 2008;26(7):1778-86. 2008 [PMID: 18483422] (Bioassay, Mouse)
• Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, Lodish HF, Zhang CC Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells, 2008;26(6):1628-35. 2008 [PMID: 18369099] (Bioassay, Human)
• Milenkovic N, Frahm C, Gassmann M, Griffel C, Erdmann B, Birchmeier C, Lewin GR, Garratt AN Nociceptive tuning by stem cell factor/c-Kit signaling. Neuron, 2007;56(5):893-906. 2007 [PMID: 18054864] (In Vivo, Mouse)
• Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J. Immunol., 2007;179(10):7128-36. 2007 [PMID: 17982105] (Bioassay, Mouse)
• Rajesh&lt;/LastName&gt;&lt;ForeNam D&lt;/Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007;25(2):490-9. 2007 [PMID: 17284653] (Bioassay, Human)
• Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ Commonly dysregulated genes in murine APL cells. Blood, 2007;109(3):961-70. 2007 [PMID: 17008535] (In Vivo, Mouse)
• Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J c-kit delineates a distinct domain of progenitors in the developing kidney. Dev. Biol., 2006;299(1):238-49. 2006 [PMID: 16942767] (Bioassay, Mouse)
• Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 2006;108(6):2041-4. 2006 [PMID: 16720837] (Bioassay, Mouse)
• Young MR Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity. Int. J. Cancer, 2006;119(1):133-8. 2006 [PMID: 16450395] (In Vivo, Mouse)
• Yilmaz OH, Kiel MJ, Morrison SJ SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood, 2005;107(3):924-30. 2005 [PMID: 16219798] (Bioassay, Mouse)
• Hofmann MC, Braydich-Stolle L, Dettin L, Johnson E, Dym M Immortalization of mouse germ line stem cells. Stem Cells, 2005;23(2):200-10. 2005 [PMID: 15671143] (Bioassay, Mouse)
• Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 2001;293(10):508-14. 2001 [PMID: 11820727] (Bioassay, Mouse)
• Gardner RV, 48657, Oliver P, Astle CM Stem cell factor improves the repopulating ability of primitive hematopoietic stem cells after sublethal irradiation (and, to a lesser extent) after bone marrow transplantation in mice. Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum, 1998;16(2):112-9. 1998 [PMID: 9554035] (In Vivo, Mouse)

Bioinformatics

• Gene Symbol: Kitl
• Uniprot:
  • Q78ED8()