Recombinant Mouse SCF Protein

Recombinant Mouse SCF/c-kit Ligand (Catalog # 455-MC) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 2.5-10 ng/mL.

1 μg/lane of Recombinant Mouse SCF/c-kit was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse SCF Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED 50 for this effect is 2.5-10 ng/mL.
• Source: E. coli-derived mouse SCF/c-kit Ligand protein Lys26-Ala189, with an N-terminal Met
• Accession #: Q78ED8
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Kitl
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 18.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 3 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse SCF Protein

• c-kit Ligand
• DCUA
• DFNA69
• DKFZp686F2250
• familial progressive hyperpigmentation 2
• FPH2
• FPHH
• KIT ligand
• Kitl
• KITLG
• KL-1
• Mast cell growth factor
• MGF
• MGFSHEP7
• SCF
• SCFStem cell factor
• SFc-Kit ligand
• SHEP7
• SLF
• steel factor

Background

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein (1). It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1 - 7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). Mature mouse SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail (9). The ECD shows both N-linked and O-linked glycosylation (10). Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice (11, 12). An alternately spliced isoform of mouse SCF lacks 28 aa that encompasses the primary proteolytic recognition site (13). Within the ECD of the short isoform (corresponding to this recombinant protein), mouse SCF shares 93% aa sequence identity with rat SCF and 72% - 75% with canine, feline, and human SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (14). Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling (15). SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (16).

1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037.
2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599. 
3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1.
4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201. 
5. Kapur, R. et al. (2002) Blood 100:1287.
6. Wang, C.-H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540.
7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 
8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327. 
9. Huang, E. et al. (1990) Cell 63:225.
10. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942.
11. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237.
12. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671.
13. Flanagan, J.G. et al. (1991) Cell 64:1025.
14. Martin, F.H. et al. (1990) Cell 63:203.
15. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311.
16. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117.

Publications for SCF/c-kit Ligand (455-MC)(185)

Publications using 455-MC

• Lehle, JD;Lin, YH;Gomez, A;Chavez, L;McCarrey, JR; An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis eLife 2024-10-03 [PMID: 39361026] (Bioassay, Transgenic Mouse)
• Pv, A;Mehatre, SH;Verfaillie, CM;Alam, MT;Khurana, S; Glycolytic state of aortic endothelium favors hematopoietic transition during the emergence of definitive hematopoiesis Science advances 2024-02-16 [PMID: 38363844] (Bioassay, Mouse)
• Brady, A;Sheneman, KR;Pulsifer, AR;Price, SL;Garrison, TM;Maddipati, KR;Bodduluri, SR;Pan, J;Boyd, NL;Zheng, JJ;Rai, SN;Hellmann, J;Haribabu, B;Uriarte, SM;Lawrenz, MB; Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition PLoS pathogens 2024-01-25 [PMID: 38271464] (Bioassay, Mouse)
• Verdikt, R;Armstrong, AA;Cheng, J;Hwang, YS;Clark, AT;Yang, X;Allard, P; Metabolic memory of ?9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells eLife 2023-12-27 [PMID: 38150302] (Cell Culture, Mouse)
• Luis, TC;Barkas, N;Carrelha, J;Giustacchini, A;Mazzi, S;Norfo, R;Wu, B;Aliouat, A;Guerrero, JA;Rodriguez-Meira, A;Bouriez-Jones, T;Macaulay, IC;Jasztal, M;Zhu, G;Ni, H;Robson, MJ;Blakely, RD;Mead, AJ;Nerlov, C;Ghevaert, C;Jacobsen, SEW; Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner Nature communications 2023-09-28 [PMID: 37770432] (Bioassay, Mouse)
• Jindal, K;Adil, MT;Yamaguchi, N;Yang, X;Wang, HC;Kamimoto, K;Rivera-Gonzalez, GC;Morris, SA; Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes Nature biotechnology 2023-09-25 [PMID: 37749269] (Bioassay, Mouse)
• Williams, O;Hu, L;Huang, W;Patel, P;Bartom, ET;Bei, L;Hjort, E;Hijiya, C;Eklund, EA; Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis, but facilitates termination of emergency (stress) granulopoiesis The Journal of biological chemistry 2023-05-27 [PMID: 37247756] (Bioassay, Mouse)
• Lee, HJ;Lee, J;Yang, MJ;Kim, YC;Hong, SP;Kim, JM;Hwang, GS;Koh, GY; Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes Nature communications 2023-05-13 [PMID: 37179330] (Bioassay, Mouse)
• H Huang, Y Li, G Zhang, GX Ruan, Z Zhu, W Chen, J Zou, R Zhang, J Wang, Y Ouyang, S Xu, X Ou The RNA-binding protein hnRNP F is required for the germinal center B cell response Nature Communications, 2023-03-30;14(1):1731. 2023-03-30 [PMID: 36997512] (Bioassay, Mouse)
• X Cui, C Zhang, F Wang, X Zhao, S Wang, J Liu, D He, C Wang, FC Yang, S Tong, Y Liang Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 Cell Reports, 2023-03-16;42(3):112274. 2023-03-16 [PMID: 36933218] (Bioassay, Mouse)
• Qing Luo, Han-pin Pui, Jiayu Chen, Leqian Yu, Paulo R. Jannig, Yu Pei et al. Epiblast-like stem cells established by Wnt/ beta -catenin signaling manifest distinct features of formative pluripotency and germline competence Cell Reports 2023-01-31 [PMID: 36848234] (Bioassay, Mouse)
• M Shono, K Kishimoto, O Hikabe, M Hayashi, K Semi, Y Takashima, E Sasaki, K Kato, K Hayashi Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling Scientific Reports, 2023-02-23;13(1):3186. 2023-02-23 [PMID: 36823310] (Bioassay, Human)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Mouse)
• M Uslu, E Albayrak, F Kocaba? Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) content International immunopharmacology, 2022-07-11;110(0):109035. 2022-07-11 [PMID: 35834953] (Bioassay, Mouse)
• Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Mouse)
• J Jeong, I Jung, JH Kim, S Jeon, DY Hyeon, H Min, B Kang, J Nah, D Hwang, SJ Um, M Ko, RH Seong BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells Cell Death and Differentiation, 2022-04-26;0(0):. 2022-04-26 [PMID: 35473985] (Bioassay, Mouse)
• Q Zhang, L Zhao, Y Yang, S Li, Y Liu, C Chen Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132955] (Bioassay, Mouse)
• BE Thacker, KJ Thorne, C Cartwright, J Park, K Glass, A Chea, BP Kellman, NE Lewis, Z Wang, A Di Nardo, ST Sharfstein, W Jeske, J Walenga, J Hogwood, E Gray, B Mulloy, JD Esko, CA Glass Multiplex genome editing of mammalian cells for producing recombinant heparin Metabolic engineering, 2022-01-14;0(0):. 2022-01-14 [PMID: 35038554] (Bioassay, Mouse)
• R Deshycka, V Sudaryo, NJ Huang, Y Xie, LY Smeding, MK Choi, HL Ploegh, HF Lodish, N Pishesha Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity PLoS ONE, 2021-11-03;16(11):e0259353. 2021-11-03 [PMID: 34731223] (Bioassay, Mouse)
• T Kobayashi, A Castillo-V, CA Penfold, M Morgan, N Mizuno, WWC Tang, Y Osada, M Hirao, F Yoshida, H Sato, H Nakauchi, M Hirabayash, MA Surani Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells Cell Reports, 2021-10-12;37(2):109812. 2021-10-12 [PMID: 34644585] (Bioassay, Rabbit)
• HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 2021-10-08;7(41):eabg4167. 2021-10-08 [PMID: 34623912] (Bioassay, Mouse)
• SR Naidu, M Capitano, J Ropa, S Cooper, X Huang, HE Broxmeyer Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects Leukemia, 2021-10-01;0(0):. 2021-10-01 [PMID: 34599272] (Bioassay, Mouse)
• Y Ishikura, H Ohta, T Sato, Y Murase, Y Yabuta, Y Kojima, C Yamashiro, T Nakamura, T Yamamoto, T Ogawa, M Saitou In�vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells Cell Stem Cell, 2021-09-07;0(0):. 2021-09-07 [PMID: 34496297] (Bioassay, Mouse)
• C Zhao, Y Zhao, J Zhao, G Meng, S Huang, Y Liu, S Wang, L Qi Acute myeloid leukemia cell-derived extracellular vesicles carrying microRNA-548ac regulate hematopoietic function via the TRIM28/STAT3 pathway Cancer Gene Therapy, 2021-08-27;0(0):. 2021-08-27 [PMID: 34453123] (Bioassay, Mouse)
• K Yamamoto, S Goyama, S Asada, T Fujino, T Yonezawa, N Sato, R Takeda, A Tsuchiya, T Fukuyama, Y Tanaka, A Yokoyama, H Toya, A Kon, Y Nannya, R Onoguchi-M, S Nakagawa, T Hirose, S Ogawa, N Akimitsu, T Kitamura A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells Cell Reports, 2021-08-24;36(8):109576. 2021-08-24 [PMID: 34433054] (Bioassay, Mouse)
• N Ohashi, T Terashima, M Katagi, Y Nakae, J Okano, Y Suzuki, H Kojima GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS Scientific Reports, 2021-06-17;11(1):12803. 2021-06-17 [PMID: 34140581] (Cell Culture, Mouse)
• F Herbst, TJL Lang, ESP Eckert, P Wünsche, AA Wurm, T Kindinger, K Laaber, S Hemmati, A Hotz-Wagen, O Zavidij, A Paruzynski, J Lu, C von Kalle, T Zenz, C Klein, M Schmidt, CR Ball, H Glimm The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision Leukemia, 2021-05-21;0(0):. 2021-05-21 [PMID: 34021250] (Bioassay, Mouse)
• RA Cardenas, R Gonzalez, E Sanchez, MA Ramos, EI Cardenas, AI Rodarte, RJ Alcazar-Fe, A Isaza, AR Burns, R Heidelberg, R Adachi SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis The Journal of Biological Chemistry, 2021-01-08;296(0):100268. 2021-01-08 [PMID: 33837726] (Cell Culture, Mouse)
• J Lu, S Li, X Li, W Zhao, X Duan, X Gu, J Xu, B Yu, LJ Sigal, Z Dong, L Xie, M Fang Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging Aging Cell, 2021-03-29;0(0):e13353. 2021-03-29 [PMID: 33780118] (Bioassay, Mouse)
• AK Persaud, S Nair, MF Rahman, R Raj, B Weadick, D Nayak, C McElroy, M Shanmugam, S Knoblaugh, X Cheng, R Govindaraj Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors Nature Communications, 2021-02-23;12(1):1248. 2021-02-23 [PMID: 33623001] (Bioassay)
• X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li Formative pluripotent stem cells show features of epiblast cells poised for gastrulation Cell Research, 2021-02-19;0(0):. 2021-02-19 [PMID: 33608671] (Bioassay, Mouse)
• S Takashima, S Usui, O Inoue, C Goten, K Yamaguchi, Y Takeda, S Cui, Y Sakai, K Hayashi, K Sakata, MA Kawashiri, M Takamura Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells Scientific Reports, 2021-01-15;11(1):1520. 2021-01-15 [PMID: 33452355] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• Y Hong, N Singh, S Bamopoulos, E Gjerga, LK Schmalbroc, K Balabanian, M Schick, U Keller, M Wirth Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System Biomedicines, 2020-12-09;8(12):. 2020-12-09 [PMID: 33317212] (Bioassay, Mouse)
• K Spinler, J Bajaj, T Ito, B Zimdahl, M Hamilton, A Ahmadi, CS Koechlein, N Lytle, HY Kwon, F Anower-E-K, H Sun, A Blevins, J Weeks, M Kritzik, J Karlseder, MH Ginsberg, PW Park, JD Esko, T Reya A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia Nat Commun, 2020-11-26;11(1):5998. 2020-11-26 [PMID: 33243988] (Cell Culture, Mouse)
• T Trinh, J Ropa, A Aljoufi, S Cooper, A Sinn, EF Srour, HE Broxmeyer Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells Leukemia, 2020-11-07;0(0):. 2020-11-07 [PMID: 33159180] (Cell Culture, Mouse)
• M Girotra, V Trachsel, A Roch, MP Lutolf In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro Int J Mol Sci, 2020-11-03;21(21):. 2020-11-03 [PMID: 33153113] (Cell Culture, Mouse)
• M Wada, Y Shimada, S Iizuka, N Ishii, H Hiraki, T Tachibana, K Maeda, M Saito, S Arakawa, T Ishimoto, T Nakano, H Ida, T Ohashi, H Kobayashi Ex�Vivo Gene Therapy Treats Bone Complications of Mucopolysaccharidosis Type II Mouse Models through Bone Remodeling Reactivation Mol Ther Methods Clin Dev, 2020-09-20;19(0):261-274. 2020-09-20 [PMID: 33102618] (Bioassay, Mouse)
• H Huang, CA Howard, S Zari, HJ Cho, S Shukla, H Li, J Ndoj, P González-A, C Nikolaidis, J Abbott, DS Rogawski, MA Potopnyk, K Kempinska, H Miao, T Purohit, A Henderson, A Mapp, ML Sulis, A Ferrando, J Grembecka, T Cierpicki Covalent inhibition of NSD1 histone methyltransferase Nat. Chem. Biol., 2020-08-31;0(0):. 2020-08-31 [PMID: 32868895] (Bioassay, Mouse)
• V Peng, C Georgescu, A Bakowska, A Pankow, L Qian, JD Wren, XH Sun E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 2020-08-19;0(0):. 2020-08-19 [PMID: 32817168] (Bioassay, Cell Culture, Mouse)
• C Cho, R Mukherjee, AR Peck, Y Sun, N McBrearty, KV Katlinski, J Gui, PK Govindaraj, E Puré, H Rui, SY Fuchs Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis Oncogene, 2020-08-17;0(0):. 2020-08-17 [PMID: 32807917] (Bioassay, Mouse)
• NV Bogert, J Furkel, S Din, I Braren, V Eckstein, JA Müller, L Uhlmann, HA Katus, MH Konstandin A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus Sci Rep, 2020-08-13;10(1):13740. 2020-08-13 [PMID: 32792615] (Bioassay, Mouse)
• L Garcia-Per, M van Eggerm, L van Roon, SA Vloemans, M Cordes, A Schambach, M Rothe, D Berghuis, C Lagresle-P, M Cavazzana, F Zhang, AJ Thrasher, D Salvatori, P Meij, A Villa, JJM Van Dongen, JJ Zwaginga, M van der Bu, HB Gaspar, A Lankester, FJT Staal, K Pike-Overz Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID Mol Ther Methods Clin Dev, 2020-03-31;17(0):666-682. 2020-03-31 [PMID: 32322605] (Bioassay, Mouse)
• C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou Generation of human oogonia from induced pluripotent stem cells in culture Nat Protoc, 2020-03-30;15(4):1560-1583. 2020-03-30 [PMID: 32231324] (Bioassay, Human)
• S Kreutmair, C Klingeberg, T Poggio, G Andrieux, A Keller, C Miething, M Follo, D Pfeifer, K Shoumariye, C Lengerke, I Gonzalez-M, F Fend, R Zeiser, SD Turner, L Quintanill, M Boerries, J Duyster, AL Illert Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model Leukemia, 2020-03-17;0(0):. 2020-03-17 [PMID: 32203142] (Cell Culture, Mouse)
• A Yoshimi, TM Trippett, N Zhang, X Chen, AV Penson, ME Arcila, J Pichardo, J Baik, A Sigler, H Harada, DC Fajgenbaum, A Dogan, O Abdel-Waha, W Xiao Genetic basis for iMCD-TAFRO Oncogene, 2020-02-12;0(0):. 2020-02-12 [PMID: 32051554] (Bioassay, Mouse)
• JM Bertho, D Kereselidz, L Manens, C Culeux, V Magneron, J Surette, M Blimkie, L Bertrand, H Wyatt, M Souidi, I Dublineau, N Priest, JR Jourdain Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism Sci Rep, 2019-12-27;9(1):19919. 2019-12-27 [PMID: 31882739] (Multiplex Standard, Mouse)
• T Fukushima, Y Tanaka, FK Hamey, CH Chang, T Oki, S Asada, Y Hayashi, T Fujino, T Yonezawa, R Takeda, KC Kawabata, T Fukuyama, T Umemoto, K Takubo, H Takizawa, S Goyama, Y Ishihama, H Honda, B Göttgens, T Kitamura Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium Cell Rep, 2019-12-17;29(12):4144-4158.e7. 2019-12-17 [PMID: 31851939] (Cell Culture, Mouse)
• R Magadmi, J Meszaros, ZA Damanhouri, EP Seward Secretion of Mast Cell Inflammatory Mediators Is Enhanced by CADM1-Dependent Adhesion to Sensory Neurons Front Cell Neurosci, 2019-06-18;13(0):262. 2019-06-18 [PMID: 31275114] (Bioassay, Mouse)
• S Nair, AM Strohecker, AK Persaud, B Bissa, S Muruganand, C McElroy, R Pathak, M Williams, R Raj, A Kaddoumi, A Sparreboom, AM Beedle, R Govindaraj Adult stem cell deficits drive Slc29a3 disorders in mice Nat Commun, 2019-07-03;10(1):2943. 2019-07-03 [PMID: 31270333] (Cell Culture, Mouse)
• XU Haiqian, W Li, S Luo, J Yuan, L Hao Adipose derived stem cells promote tumor metastasis in breast Cancer cells by stem cell factor inhibition of miR20b Cell. Signal., 2019-06-27;62(0):109350. 2019-06-27 [PMID: 31254605] (Bioassay, Mouse)
• ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 2019-05-20;130(0):2555-2570. 2019-05-20 [PMID: 31107242] (Bioassay, Human, Mouse)
• YL Chang, Z Wang, S Igawa, JE Choi, T Werbel, A Di Nardo Lipocalin 2: A New Antimicrobial in Mast Cells Int J Mol Sci, 2019-05-14;20(10):. 2019-05-14 [PMID: 31091692] (Cell Culture, Mouse)
• SK Nandakumar, SK McFarland, LM Mateyka, CA Lareau, JC Ulirsch, LS Ludwig, G Agarwal, JM Engreitz, B Przychodze, M McConkey, GS Cowley, JG Doench, JP Maciejewsk, BL Ebert, DE Root, VG Sankaran Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis Elife, 2019-05-09;8(0):. 2019-05-09 [PMID: 31070582] (Bioassay, Mouse)
• MJ Delás, BT Jackson, T Kovacevic, S Vangelisti, E Munera Mar, SA Wild, EM Stork, N Erard, SRV Knott, GJ Hannon lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation Cell Rep, 2019-04-16;27(3):719-729.e6. 2019-04-16 [PMID: 30995471] (cell culture media, Mouse)
• S Mayers, PD Moço, T Maqbool, PN Silva, DM Kilkenny, J Audet Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector BMC Biotechnol., 2019-04-15;19(1):21. 2019-04-15 [PMID: 30987611] (Bioassay, Mouse)
• C Li, L Dong, R Su, Y Bi, Y Qing, X Deng, Y Zhou, C Hu, M Yu, H Huang, X Jiang, X Li, X He, D Zou, C Shen, L Han, M Sun, J Skibbe, K Ferchen, X Qin, H Weng, H Huang, C Song, J Chen, J Jin Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC Haematologica, 2019-04-11;0(0):. 2019-04-11 [PMID: 30975912] (Bioassay, Mouse)
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• Li B, Baylink D, Walter M, Lau K, Meng X, Wang J, Cherkas A, Tang X, Qin X Targeted 25-hydroxyvitamin D3 1alpha-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice. Mol Ther, 2014-10-20;23(2):339-51. 2014-10-20 [PMID: 25327179] (Bioassay, Mouse)
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• Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment. Sci Rep, 2014-08-28;4(0):6222. 2014-08-28 [PMID: 25164363] (Bioassay, Mouse)
• Luyten A, Zang C, Liu X, Shivdasani R Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev, 2014-08-15;28(16):1827-39. 2014-08-15 [PMID: 25128499] (Bioassay, Mouse)
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• Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood, 2014-07-02;124(9):1393-403. 2014-07-02 [PMID: 24990886] (Bioassay, Mouse)
• Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer M, Zhang H, Hogquist K, Evavold B, Vignali D TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol, 2014-06-18;193(2):571-9. 2014-06-18 [PMID: 24943217] (Bioassay, Mouse)
• Hiragun T, Yanase Y, Okabe T, Hiragun M, Kawai M, Hide M Establishment of a mast cell line, NCL-2, without Kit mutation, derived from NC mouse bone marrow. FEBS Open Bio, 2014-04-02;4(0):342-6. 2014-04-02 [PMID: 24918047] (Bioassay, Mouse)
• Fukuda , S, Hoggatt , J, Singh , P, Abe , M, Speth , J M, Hu , P, Conway , E M, Nucifora , G, Yamaguchi , S, Pelus , L M Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. Leukemia, 2014-06-06;29(2):433-40. 2014-06-06 [PMID: 24903482] (Bioassay, Mouse)
• Patnode M, Bando J, Krummel M, Locksley R, Rosen S Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med, 2014-06-02;211(7):1281-8. 2014-06-02 [PMID: 24889202] (Bioassay, Mouse)
• Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata K, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood, 2014-05-13;123(25):3932-42. 2014-05-13 [PMID: 24825862] (Bioassay, Mouse)
• Nagareddy P, Kraakman M, Masters S, Stirzaker R, Gorman D, Grant R, Dragoljevic D, Hong E, Abdel-Latif A, Smyth S, Choi S, Korner J, Bornfeldt K, Fisher E, Dixit V, Tall A, Goldberg I, Murphy A Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab, 2014-05-06;19(5):821-35. 2014-05-06 [PMID: 24807222] (Bioassay, Mouse)
• Nam T, Park K, Shawl A, Kim B, Han M, Kim Y, Moss J, Kim U Critical role for NAD glycohydrolase in regulation of erythropoiesis by hematopoietic stem cells through control of intracellular NAD content. J Biol Chem, 2014-04-23;289(23):16362-73. 2014-04-23 [PMID: 24759100] (Bioassay, Rabbit)
• Park S, Umemoto T, Saito-Adachi M, Shiratsuchi Y, Yamato M, Nakai K Computational promoter modeling identifies the modes of transcriptional regulation in hematopoietic stem cells. PLoS ONE, 2014-04-07;9(4):e93853. 2014-04-07 [PMID: 24710559] (Bioassay, Mouse)
• Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res, 2014-03-31;74(10):2803-15. 2014-03-31 [PMID: 24686171] (Bioassay, Mouse)
• Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK. PLoS ONE, 2014-02-26;9(2):e89649. 2014-02-26 [PMID: 24586935] (Bioassay, Mouse)
• Chung , Jie-Yu, Figgett , William, Fairfax , Kirsten, Bernard , Claude, Chan , James, Toh , Ban-Hock, Mackay , Fabienne, Alderuccio , Frank Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion. J Immunol, 2014-02-14;192(6):2593-601. 2014-02-14 [PMID: 24532581] (Bioassay, Mouse)
• Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells. Immunology, 2014-07-01;142(3):421-30. 2014-07-01 [PMID: 24527810] (Bioassay, Mouse)
• Zimdahl , Bryan, Ito , Takahiro, Blevins , Allen, Bajaj , Jeevisha, Konuma , Takaaki, Weeks , Joi, Koechlein , Claire S, Kwon , Hyog You, Arami , Omead, Rizzieri , David, Broome , H Elizab, Chuah , Charles, Oehler , Vivian G, Sasik , Roman, Hardiman , Gary, Reya , Tannisht Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet, 2014-02-02;46(3):245-52. 2014-02-02 [PMID: 24487275] (Bioassay, Mouse)
• Reber L, Daubeuf F, Pejler G, Abrink M, Frossard N Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J Immunol, 2014-01-22;192(4):1847-54. 2014-01-22 [PMID: 24453258] (Bioassay, Mouse)
• Roderick , Justine, Tesell , Jessica, Shultz , Leonard, Brehm , Michael, Greiner , Dale L, Harris , Marian H, Silverman , Lewis B, Sallan , Stephen, Gutierrez , Alejandr, Look , A Thomas, Qi , Jun, Bradner , James E, Kelliher , Michelle c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood, 2014-01-06;123(7):1040-50. 2014-01-06 [PMID: 24394663] (Bioassay, Mouse)
• North , Matthew, Shuga , Joe, Fromowitz , Michele, Loguinov , Alexandr, Shannon , Kevin, Zhang , Luoping, Smith , Martyn T, Vulpe , Chris D Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer, 2014-01-05;14(0):6. 2014-01-05 [PMID: 24386979] (Bioassay, Mouse)
• Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports, 2013-11-27;1(6):545-59. 2013-11-27 [PMID: 24371809] (Bioassay, Mouse)
• Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells. Exp Cell Res, 2013-09-27;320(1):54-61. 2013-09-27 [PMID: 24080013] (Bioassay, Mouse)
• Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka I, Dyer M, Baron M Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells, 2014-01-01;32(1):191-203. 2014-01-01 [PMID: 24022884] (Bioassay, Mouse)
• Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, Clark N, Nomura-Kitabayashi A, Kovacic J, Ma'ayan A, Schaniel C, Lemischka I, Moore K Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell, 2013-06-13;13(2):205-18. 2013-06-13 [PMID: 23770078] (Bioassay, Mouse)
• Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol, 2013-03-06;43(4):979-88. 2013-03-06 [PMID: 23404570] (Bioassay, Mouse)
• Jeong H, Oh H, Nam S, Han N, Kim Y, Kim J, Lee S, Kim M, Moon P, Kim H, Oh H The critical role of mast cell-derived hypoxia-inducible factor-1alpha in human and mice melanoma growth. Int J Cancer, 2012-12-03;132(11):2492-501. 2012-12-03 [PMID: 23161568] (Bioassay, Mouse)
• Kinzfogl J, Hangoc G, Broxmeyer HE Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. Blood, 2011-05-31;118(3):565-75. 2011-05-31 [PMID: 21628410] (Bioassay, Mouse)
• Cook BD, Liu S, Evans T Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood, 2011-04-22;117(24):6489-97. 2011-04-22 [PMID: 21515822] (Bioassay, Mouse)
• Artus J, Panthier JJ, Hadjantonakis AK A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst. Development, 2010-09-08;137(20):3361-72. 2010-09-08 [PMID: 20826533] (Bioassay, Mouse)
• Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J. Immunol., 2009-06-26;183(2):925-36. 2009-06-26 [PMID: 19561101] (Bioassay, Mouse)
• Dolgachev VA, Ullenbruch MR, Lukacs NW, Phan SH Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling. Am. J. Pathol., 2009-01-15;174(2):390-400. 2009-01-15 [PMID: 19147822] (In Vivo, Mouse)
• Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood, 2008-08-11;112(9):3878-88. 2008-08-11 [PMID: 18694996] (Bioassay, Mouse)
• Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells, 2008-05-15;26(7):1778-86. 2008-05-15 [PMID: 18483422] (Bioassay, Mouse)
• Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, Lodish HF, Zhang CC Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells, 2008-03-27;26(6):1628-35. 2008-03-27 [PMID: 18369099] (Bioassay, Human, Mouse)
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• Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J. Immunol., 2007-11-15;179(10):7128-36. 2007-11-15 [PMID: 17982105] (Bioassay, Mouse)
• Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Human, Mouse, Primate - Macaca mulatta (Rhesus Macaque))
• Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ Commonly dysregulated genes in murine APL cells. Blood, 2006-09-28;109(3):961-70. 2006-09-28 [PMID: 17008535] (In Vivo, Mouse)
• Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J c-kit delineates a distinct domain of progenitors in the developing kidney. Dev. Biol., 2006-07-31;299(1):238-49. 2006-07-31 [PMID: 16942767] (Bioassay, Mouse)
• Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 2006-05-23;108(6):2041-4. 2006-05-23 [PMID: 16720837] (Bioassay, Mouse)
• Young MR Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity. Int. J. Cancer, 2006-07-01;119(1):133-8. 2006-07-01 [PMID: 16450395] (In Vivo, Mouse)
• Yilmaz OH, Kiel MJ, Morrison SJ SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood, 2005-10-11;107(3):924-30. 2005-10-11 [PMID: 16219798] (Bioassay, Mouse)
• Yoshihiro Ueda, Motonari Kondo, Garnett Kelsoe Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow The Journal of Experimental Medicine 2005-06-06 [PMID: 15939792] (ELISA Control, Mouse)
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Bioinformatics

• Gene Symbol: Kitl
• Uniprot:
  • Q78ED8()