Raf-1 [p Ser259] Antibody

Product Discontinued

Raf-1 [p Ser259] Antibody Summary

• Immunogen: Synthetic phospho-peptide surrounding amino acid Ser259 of human c-Raf.
• Modification: p Ser259
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RAF1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 1% BSA, 50% Glycerol
• Preservative: 0.02% Thimerosal
• Concentration: 0.5 mg/ml
• Purity: Affinity purified

Alternate Names for Raf-1 [p Ser259] Antibody

• cRaf
• c-Raf
• c-Raf-1
• CRAFraf proto-oncogene serine/threonine protein kinase
• EC 2.7.11
• EC 2.7.11.1
• NS5
• Proto-oncogene c-RAF
• RAF proto-oncogene serine/threonine-protein kinase
• RAF
• Raf1
• Raf-1
• Raf-1Oncogene RAF1
• v-raf-1 murine leukemia viral oncogene homolog 1
• v-Raf-1

Background

Raf-1(v-raf-1 murine leukemia viral oncogene homolog 1), with 648-amino acid protein (about 71 kDa), is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and Raf-1).The Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) pathway participates in the control of many fundamental cellular processes including proliferation, survival, and differentiation. The pathway is deregulated in up to 30% of human cancers, often due to mutations in Ras and the bRaf isoform. Raf-1 and bRaf can form heterodimers, and this may be important for cellular transformation. Raf-1 inhibition is also associated with apoptotic cell death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: RAF1
• Entrez:
  • 5894(Human)
• Uniprot:
  • P04049()