QuicKit Control for Human Granulysin

• Reactivity: Hu

QuicKit Control for Human Granulysin Summary

• Additional Information: Control Set 1253
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for QuicKit Control for Human Granulysin

• D2S69Elymphocyte-activation gene 2
• GNLY
• Granulysin
• LAG2
• LAG-2
• Lymphokine LAG-2
• Lymphokine
• NKG5
• NKG5519
• Protein NKG5
• TLA519
• TLA519T-cell activation protein 519
• T-lymphocyte activation gene 519

Background

Granulysin, formerly known as NKG5 or Lymphokine LAG-2, is a membrane-lytic protein that is expressed in granules of natural killer and activated cytotoxic T cells. It exhibits cytolytic activity against intracellular or extracellular microbes and also tumors, either alone or in synergy with Perforin. IL-15 is necessary and sufficient for Granulysin release from CD8+ T cells. Granulysin promotes chemotaxis and increases production of chemokines by monocytic cells as well as target cell lysis. It binds and disrupts microbial membranes through charge interactions.