PSMA/FOLH1/NAALADase I Antibody (3E6)

Immunohistochemistry-Paraffin: PSMA/FOLH1/NAALADase I Antibody (3E6) [NBP2-26473] - Formalin fixed paraffin embedded prostate carcinoma stained with PSMA/FOLH1/NAALADase I antibody (NBP2-26473).

Product Discontinued

PSMA/FOLH1/NAALADase I Antibody (3E6) Summary

• Immunogen: BALB/C mice were injected with LNCaP membrane preparation and Immunoaffinity purified PSMA.
• Localization: Cytoplasmic, cell membrane
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: FOLH1
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
• Application Notes: IHC-P: recommended pretreatment of citrate buffer, pH 6.0. Recommended incubation time of 30 min at RT.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: Tissue culture supernatant
• Preservative: 0.05% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for PSMA/FOLH1/NAALADase I Antibody (3E6)

• Cell growth-inhibiting gene 27 protein
• cell growth-inhibiting protein 27
• EC 3.4.17.21
• FGCP
• folate hydrolase (prostate-specific membrane antigen) 1
• Folate hydrolase 1
• FOLH1
• FOLHNAALADase I
• Folylpoly-gamma-glutamate carboxypeptidase
• GCP2
• GCPII
• GCPIImGCP
• glutamate carboxylase II
• glutamate carboxypeptidase 2
• Glutamate carboxypeptidase II
• Membrane glutamate carboxypeptidase
• mopsm
• NAALAD1
• NAALAD1N-acetylated-alpha-linked acidic dipeptidase I
• NAALADase I
• NAALAdase
• N-acetylated alpha-linked acidic dipeptidase 1
• prostate specific membrane antigen variant F
• Prostate-specific membrane antigen
• PSMA
• PSMAFGCP
• PSMPteroylpoly-gamma-glutamate carboxypeptidase

Background

PSMA is a 100 kDa type II transmembrane glycoprotein. PSMA is expressed in normal and malignant prostatic epithelium and in a subset of non-prostatic tissues. In prostate cancer, PSMA expression has been shown to correlate with disease progression, with highest levels expressed in hormone-refractory and metastatic disease. The cellular localization of PSMA is cytoplasmic and/or membranous.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PSMA/FOLH1/NAALADase I Antibody (NBP2-26473)(1)

Publication using NBP2-26473

• Murphy GP, Greene TG, Tino WT et al. Isolation and characterization of monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen. J Urol. 1998-12-01 [PMID: 9817391]
  
  Details:
  See Section 8.2 (Results) for additional information about Clone 3E6.

Bioinformatics

• Gene Symbol: FOLH1