PP2A alpha Antibody (234532) [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: IHC
• Clone: 234532
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Janelia Fluor 646

PP2A alpha Antibody (234532) [Janelia Fluor® 646] Summary

• Immunogen: E. coli-derived recombinant human PP2A-alpha Catalytic Subunit
  Trp209-Leu309
  Accession # P67775
• Specificity: Detects human PP2A Catalytic Subunit in direct ELISAs. Because PP2A-alpha and PP2A-beta Catalytic Subunits are identical in the region used for the antigen, it is expected that both isoforms will be detected by the antibody.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: PPP2CA
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PP2A alpha Antibody (234532) [Janelia Fluor® 646]

• EC 3.1.3.16
• PP2A
• PP2A-alpha
• PP2Ac
• PP2CA
• PP2Calpha
• PPP2CA
• protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
• protein phosphatase 2, catalytic subunit, alpha isozyme
• protein phosphatase 2A catalytic subunit, alpha isoform
• Replication protein C
• RP-C
• serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
• serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Background

Protein phosphatase type 2A (PP2A ) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways. PP2A is comprised of a core enzyme (which is made up of catalytic C and regulatory A (PR65) subunits) and a secondary regulatory B subunit. PP2A alpha refers to the alpha isoform of the PP2A catalytic subunit.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPP2CA