PMP70 Antibody (EPR5614)

Product Discontinued

PMP70 Antibody (EPR5614) Summary

• Immunogen: A synthetic peptide corresponding to residues on the C-terminus in human PMP70 was used as an immunogen.
• Marker: Proxisomal Membrane Marker
• Clonality: Monoclonal
• Host: Rabbit
• Gene: ABCD3
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry 1:100 - 500
  • Immunocytochemistry/ Immunofluorescence 1:100 - 250
  • Western Blot 1:1000 - 10000

Reactivity Notes

Human, Mouse, Rat. Species cross-reactivity is based on Western Blot analysis.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for PMP70 Antibody (EPR5614)

• 70 kDa peroxisomal membrane protein
• ABC43
• ATP-binding cassette, sub-family D (ALD), member 3
• peroxisomal membrane protein 1 (70kD, Zellweger syndrome)
• Peroxisomal membrane protein-1 (70kD)
• PMP70ATP-binding cassette sub-family D member 3
• PXMP1dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))
• ZWS2

Background

PMP70 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). PMP70 is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters, which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations in PMP70 have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCD3
• Entrez:
  • 5825(Human)
• Uniprot:
  • P28288(Human)