Plakophilin 1 Antibody (10B2) [mFluor Violet 500 SE]

Plakophilin 1 Antibody (10B2) [mFluor Violet 500 SE] - Vial of mFluor Violet 500 conjugated antibody. mFluor Violet 500 is optimally excited at 410 nm by the Violet laser (405 nm) and has an emission maximum of 501 nm.

• Reactivity: Hu, Mu
• Applications: WB, Flow, ICC/IF, CyTOF-ready
• Clone: 10B2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 500 SE

Plakophilin 1 Antibody (10B2) [mFluor Violet 500 SE] Summary

• Immunogen: N-terminus of human Plakophilin 1 protein (Uniprot: Q13835)
• Epitope: aa 1-27
• Localization: Cell Surface and nuclear
• Specificity: Recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PKP1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Plakophilin 1 Antibody (10B2) [mFluor Violet 500 SE]

• B6PBand 6 protein
• MGC138829
• plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
• plakophilin-1

Background

The Plakophilin 1 gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PKP1