PKR Antibody


Western Blot: PKR Antibody [NB100-56399] - Analysis of PRKR in human Daudi cell lysate using this antibody.

Product Details

Reactivity HuSpecies Glossary
Applications WB
0.5 mg/ml

Order Details

PKR Antibody Summary

A portion of amino acids 500-550 of mouse PRKR protein were used as the immunogen.
The NCBI accession number for PRKR is NP_035293. The amino acid sequence used is 92% homologous in rat.
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.2% gelatin
0.05% Sodium Azide
0.5 mg/ml
Protein G purified

Reactivity Notes

Reacts with Human. Predicted to react with Mouse and Rat.

Alternate Names for PKR Antibody

  • double stranded RNA activated protein kinase
  • EC
  • eIF-2A protein kinase 2
  • EIF2AK1
  • EIF2AK2
  • eukaryotic translation initiation factor 2-alpha kinase 2P1/eIF-2A protein kinase
  • interferon-induced, double-stranded RNA-activated protein kinase
  • interferon-inducible double stranded RNA dependent
  • interferon-inducible elF2alpha kinase
  • Interferon-inducible RNA-dependent protein kinase
  • P68 Kinase
  • PKRp68 kinase
  • PPP1R83
  • PRKR
  • PRKRMGC126524
  • Protein Kinase R
  • Protein kinase RNA-activated


Official Gene Symbol: EIF2AK2 Gene ID: 5610 (Human) 19106(Mouse) Gene Map Locus: 2p22-p21(Human) 17 E2(Mouse) PRKR, a 68KDa protein, is an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, it plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PRKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. It induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. Its role has been implicated in tumor suppression & malignancy.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Mu
Applications: B/N, ELISA, Func, IHC, IHC-Fr
Species: Hu, Ha, Pm, Mu(-), Rt(-)
Applications: WB, ELISA, IHC, IHC-P
Species: Hu, Mu, Rt, Bv, Ca, Ch, Xp
Applications: Func-Inh
Species: Hu, Rt, Ca, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Ca
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, Flow-IC
Species: Hu
Applications: WB, IP, ICC
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Pm
Applications: WB, IHC-P
Species: Mu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA
Species: Hu, Mu, Rt
Applications: WB
Species: Hu
Applications: WB
Supplier Logo

Publications for PKR Antibody (NB100-56399) (0)

There are no publications for PKR Antibody (NB100-56399).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for PKR Antibody (NB100-56399) (0)

There are no reviews for PKR Antibody (NB100-56399). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for PKR Antibody (NB100-56399) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional PKR Antibody Products

Related Products by Gene

Bioinformatics Tool for PKR Antibody (NB100-56399)

Discover related pathways, diseases and genes to PKR Antibody (NB100-56399). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for PKR Antibody (NB100-56399)

Discover more about diseases related to PKR Antibody (NB100-56399).

Pathways for PKR Antibody (NB100-56399)

View related products by pathway.

PTMs for PKR Antibody (NB100-56399)

Learn more about PTMs related to PKR Antibody (NB100-56399).

Research Areas for PKR Antibody (NB100-56399)

Find related products by research area.

Blogs on PKR.

eIF2alpha - a regulator of global translation in response to cellular stress
Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...  Read full blog post.

PKR - Mediating cellular stress responses through multiple signaling pathways
Protein kinase R (PKR) is an intracellular stress-sensing protein that is able to detect and respond to viral infections. While PKR is able to sense and respond to a variety of signals, dsRNA is a well-characterized ligand. dsRNA produced during v...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol EIF2AK2

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB100-56399 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought