PKA R2 Antibody (RS30) [Janelia Fluor® 549]

Product Discontinued

PKA R2 Antibody (RS30) [Janelia Fluor® 549] Summary

• Immunogen: Purified regulatory subunit of cAMP-dependant protein kinase type II from bovine brain.
• Specificity: Regulatory subunit of cAMP-dependant protein kinase type II, alpha and beta.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: PRKAR2A
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PKA R2 Antibody (RS30) [Janelia Fluor® 549]

• protein kinase, cAMP-dependent, regulatory, type II, alpha
• RII-alpha subunit

Background

PKA (or cAPK) is a cyclic AMP-dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, and gene transcription (1,2). PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunits (RI and RII) have been identified, each possessing distinct cAMP binding properties and resulting in different phosphorylation states (2,3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRKAR2A