PKA R2 Antibody (H2 006 D4)

Product Discontinued

PKA R2 Antibody (H2 006 D4) Summary

• Immunogen: Column purified fraction of cAMP dependent PKA RII from human saliva.
• Localization: Cytoplasmic and Plasma membrane
• Specificity: PKA RII (H2 006 D4)
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PRKAR2A
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000
• Application Notes: Useful in WB. WB: Detects an approx. 50 kDa protein representing PKA RII in human saliva.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.05% Sodium Azide
• Concentration: This product is unpurified. The exact concentration of antibody is not quantifiable.
• Purity: Unpurified

Alternate Names for PKA R2 Antibody (H2 006 D4)

• protein kinase, cAMP-dependent, regulatory, type II, alpha
• RII-alpha subunit

Background

The type 1(RI) and type 2 (RII) subunit of cyclic AMP-dependent protein kinase A (PKA) is a polyfunctional protein that is present in most tissues and cells. The many roles of RII include: 1) the regulation of extracellular cyclic AMP levels, 2) catalyzing the phosphorylation of the transcription factor CREB, 3) aiding in the development of mammalian oocytes and 4) phosphorylation of proteins to enhance the release of neurotransmitters. Localization of PKA is coordinated through association with A-kinase anchoring proteins (AKAPs) that bind to a 14-18aa sequence in subunit RII.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRKAR2A
• Entrez:
  • 5576(Human)