PILR-beta Antibody

Images

 
Immunohistochemistry-Paraffin: PILR-beta Antibody [NBP1-52373] - Analysis of anti-PILRB antibody with human kidney at concentration 3 ug/ml.
Immunohistochemistry-Paraffin: PILR-beta Antibody [NBP1-52373] - Analysis of anti-PILRB antibody with human pancreas at concentration 3 ug/ml.
Immunohistochemistry-Paraffin: PILR-beta Antibody [NBP1-52373] - Analysis of anti-PILRB antibody with human testis at concentration 3 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

PILR-beta Antibody Summary

Immunogen
Synthetic peptide C-RVTESKGHSESWH from an internal region of human PILRB (NP_038468.3; NP_839956.1).
Specificity
Human PILRB. Both variants represent identical proteins (NP_038468.3; NP_839956.1). This antibody is expected to recognize isoform a only (NP_038468.3; NP_839956.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PILRB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 3-6 ug/ml
Application Notes
IHC: NBP1-52373 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PILR-beta Antibody

  • activating receptor PILRbeta
  • Activating receptor PILR-beta
  • Cell surface receptor FDFACT
  • cell surface receptor FDFACT1
  • cell surface receptor FDFACT2
  • FDFACT
  • FDFACT1
  • FDFACT2
  • paired immunoglobin-like receptor beta
  • paired immunoglobin-like type 2 receptor beta
  • paired immunoglobulin-like receptor beta
  • paired immunoglobulin-like type 2 receptor beta
  • PILRB
  • PILRbeta
  • PILR-beta

Background

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PILRB
Entrez
Uniprot