PDZD2/PDZK3 Antibody (787924) [HRP]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 787924
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: HRP

PDZD2/PDZK3 Antibody (787924) [HRP] Summary

• Immunogen: E. coli-derived recombinant human PDZD2
  Ser2489-Ser2839
  Accession # O15018
• Specificity: Detects human PDZD2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse PDZD2 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: PDZD2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for PDZD2/PDZK3 Antibody (787924) [HRP]

• Activated in prostate cancer protein
• AIPC
• AIPCPAPIN
• KIAA0300
• KIAA0300PDZ domain-containing protein 3
• Papin
• PDZ domain containing 2
• PDZ domain containing 3
• PDZ domain-containing protein 2
• PDZD2
• PDZK3
• Pin1

Background

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDZD2