PDZD2/PDZK3 Products

Description

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Uniprot	O15018 Human
Product By Gene ID	23037
Alternate Names	Activated in prostate cancer protein AIPCPAPIN KIAA0300PDZ domain-containing protein 3 PDZ domain containing 2 PDZ domain containing 3 PDZ domain-containing protein 2 PDZK3 PIN1