PDE6 beta Antibody [Janelia Fluor® 669]

Product Discontinued

PDE6 beta Antibody [Janelia Fluor® 669] Summary

• Immunogen: phosphodiesterase 6B, cGMP-specific, rod, beta. (Uniprot# P35913)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDE6B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PDE6 beta Antibody [Janelia Fluor® 669]

• CSNB3
• EC 3.1.4
• EC 3.1.4.35
• GMP-PDE beta
• PDE6 beta
• PDE6B
• PDEB
• PDEBrod cGMP-phosphodiesterase beta-subunit
• phosphodiesterase 6B, cGMP-specific, rod, beta
• rd1
• rod cGMP-specific 3'-5'-cyclic phosphodiesterase subunit beta
• RP40CSNBAD2

Background

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDE6B