PDE2A Antibody

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Immunohistochemistry-Paraffin: PDE2A Antibody [NB110-40464] - Analysis of anti-PDE2A antibody with human kidney at concentration 20 ug/ml.

Product Details

Summary
Reactivity Hu, Ca, Eq, Mu, Rt, Bv, Mk, Pm, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

PDE2A Antibody Summary

Immunogen
Synthetic 17 amino acid peptide from N-terminus of human PDE2A.
Epitope
N-terminal region of human
Localization
Cell Membrane
Specificity
Human PDE2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCNH2 (59%).
Predicted Species
Mouse (94%), Rat (94%), Bovine (94%), Monkey (94%), Rabbit (94%), Primate (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PDE2A
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 20 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Panda (100%), Gibbon (94%), Elephant (94%), Porcine (88%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PDE2A Antibody

  • cGMP-dependent 3'-5'-cyclic phosphodiesterase
  • cGMP-stimulated phosphodiesterase 1
  • cGMP-stimulated phosphodiesterase 4
  • cGSPDE
  • CGS-PDE
  • Cyclic GMP-stimulated phosphodiesterase
  • EC 3.1.4
  • EC 3.1.4.17
  • PDE2A1
  • PED2A4
  • phosphodiesterase 2A, cGMP-stimulated

Background

Phosphodiesterase 2A is a cGMP stimulated, cAMP/cGMP dual-specific phosphodiesterase whose hydrolytic activity is stimulated by the presence of cGMP binding to the GAF domain. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transit across the endothelial cell barrier (i.e., venous and capillary). PDE2A activity is inhibited by erythro-9-(2-hydroxyl-3-nonyl)adenine (EHNA). At least three isoforms have been reported (PDE2A1, PDE2A2, and PDE2A3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PDE2A
Entrez