PDE2A Antibody

Immunohistochemistry-Paraffin: PDE2A Antibody [NB110-40464] - Analysis of anti-PDE2A antibody with human kidney at concentration 20 ug/ml.

Product Discontinued

PDE2A Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from N-terminus of human PDE2A.
• Epitope: N-terminal region of human
• Localization: Cell Membrane
• Specificity: Human PDE2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCNH2 (59%).
• Predicted Species: Mouse (94%), Rat (94%), Primate (94%), Monkey (94%), Bovine (94%), Rabbit (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDE2A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 20 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Gibbon (94%), Porcine (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PDE2A Antibody

• cGMP-dependent 3'-5'-cyclic phosphodiesterase
• cGMP-stimulated phosphodiesterase 1
• cGMP-stimulated phosphodiesterase 4
• cGSPDE
• CGS-PDE
• Cyclic GMP-stimulated phosphodiesterase
• EC 3.1.4
• EC 3.1.4.17
• PDE2A
• PDE2A1
• PED2A4
• phosphodiesterase 2A, cGMP-stimulated

Background

Phosphodiesterase 2A is a cGMP stimulated, cAMP/cGMP dual-specific phosphodiesterase whose hydrolytic activity is stimulated by the presence of cGMP binding to the GAF domain. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transit across the endothelial cell barrier (i.e., venous and capillary). PDE2A activity is inhibited by erythro-9-(2-hydroxyl-3-nonyl)adenine (EHNA). At least three isoforms have been reported (PDE2A1, PDE2A2, and PDE2A3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDE2A
• Entrez:
  • 5138(Human)