Pannexin-2 Antibody (S121A-31)

Product Discontinued

Pannexin-2 Antibody (S121A-31) Summary

• Immunogen: Fusion protein amino acids 11-664 (all but first 10 amino acids, encompassing extracellular and cytoplasmic domains) of rat Pannexin-2
• Localization: Cell Membrane , Cell Junction , Gap Junction
• Specificity: Detects approx 70kDa. Does not cross-react with Pannexin-1 or Pannexin-3.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PANX2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Western Blot 1ug/ml
• Application Notes: 1 ug/ml of Pannexin-2 Antibody was sufficient for detection of Pannexin-2 in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary Antibody.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 50% Glycerol
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein G purified

Alternate Names for Pannexin-2 Antibody (S121A-31)

• hPANX2
• MGC119432
• pannexin 2
• Pannexin2
• Pannexin-2
• PANX2
• PX2

Background

The protein encoded by the Pannexin 2 gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PANX2
• Uniprot:
  • P60571(Rat)