PAK6 Antibody

Immunohistochemistry-Paraffin: PAK6 Antibody [NLS7962] - Analysis of anti-PAK6 antibody with human brain, neurons and glia.

Product Discontinued

PAK6 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from Linker domain of human PAK6.
• Specificity: Human PAK6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AGBL5 (42%).
• Predicted Species: Monkey (95%), Bovine (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PAK6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4.8 ug/ml
• Control:

  PAK6 Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Orangutan (100%), Gibbon (100%), Panda (95%), Marmoset (89%), Rat (89%), Elephant (89%), Bat (89%), Canine (89%), Rabbit (89%), Equine (89%), Mouse (84%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PAK6 Antibody

• EC 2.7.11
• p21 protein (Cdc42/Rac)-activated kinase 6
• p21(CDKN1A)-activated kinase 6
• p21-activated kinase 6
• p21-activated protein kinase 6
• PAK-5
• PAK5EC 2.7.11.1
• PAK6
• PAK-6
• serine/threonine-protein kinase PAK 6

Background

PAK6, a PAK (STE20) type protein kinase, contains a N-terminal Cdc42/Rac interactive binding (CRIB) motif and a C-terminal kinase domain. The protein has been shown to bind to GTP-Cdc42 and GTP-Rac; however, in contrast to most PAKs, kinase activity was not stimulated by Cdc42 or Rac, but could be stimulated by androgen receptor (AR) binding. PAK6 protein also has been shown to bind to estrogen receptor alpha. PAK6 expression has been documented in normal human brain, breast, prostate and testis. ESTs have been isolated from several tissue libraries, including normal brain and testis and cancerous cervix and smooth muscle. Caution: PAK6 also has been called P21-Activated Kinase 5 (PAK5); however, PAK5 is a distinct gene found on chromosome 20 p12.2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PAK6
• Entrez:
  • 56924(Human)