PAK3 Antibody [DyLight 488]

• Reactivity: Hu, Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: DyLight 488

PAK3 Antibody [DyLight 488] Summary

• Immunogen: E. coli-derived recombinant human PAK3
  Leu138-Gln255
  Accession # O75914
• Specificity: Detects human PAK3 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) PAK1, rhPAK1B, rhPAK2, rhPAK4, rhPAK6, and rhPAK7 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PAK3
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PAK3 Antibody [DyLight 488]

• beta-PAK
• bPAK
• CDKN1A
• EC 2.7.11
• EC 2.7.11.1
• hPAK3
• mental retardation, X-linked 47
• MRX30
• MRX47
• oligophrenin-3
• OPHN3
• p21 (CDKN1A)-activated kinase 3
• p21 protein (Cdc42/Rac)-activated kinase 3
• p21-activated kinase 3
• PAK3
• PAK-3
• PAK3beta
• serine/threonine-protein kinase PAK 3

Background

p21-activated kinase 3 (PAK3) is a member of a family of serine/threonine protein kinase defined by their interaction with the small GTPases, Cdc42 and Rac (1-2). The PAK proteins can be essentially divided into two categories, group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK5 and PAK6), based on their structures (3). All six PAKs play an important role in diverse cellular processes, including cytoskeletal dynamics, growth/apoptotic signal transduction through MAP kinases, and regulation of transcription factors (4). PAK3 as well as PAK1 are mostly expressed in the nervous system and particularly in the hippocampus, in which they show a diffuse distribution throughout the soma and proximal dendrites (5). Mutations in PAK3 have been linked to nonsyndromic X-linked mental retardation (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PAK3