PAC1R Antibody

Immunohistochemistry-Paraffin: PAC1R Antibody [NLS948] - Analysis of anti-ADCYAP1R1 / PAC1 Receptor antibody with human ovary, carcinoma.

Immunohistochemistry: PAC1R Antibody [NLS948] - Staining of human brain, pituitary using this antibody at 15 ug/ ml.

• Reactivity: Hu, Bt, Ca, Ch, Mk, Pm, Xp, Fi, Ze
• Applications: IHC, IHC-P
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 1.0 mg/ml

PAC1R Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from C-terminus of human ADCYAP1R1.
• Localization: Cell Membrane
• Specificity: Human ADCYAP1R1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Zebrafish (94%), Fish (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADCYAP1R1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 15 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Lizard (100%), Stickleback (94%), Pufferfish (94%0, Mouse (88%), Rat (88%), Hamster (88%), Elephant (88%), Bovine (88%), Equine (88%), Porcine (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PAC1R Antibody

• ADCYAP1R1
• adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1
• adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
• PAC1R
• PACAP type I receptor
• PACAPR
• PACAP-R1
• PACAP-R-1
• PACAPRI
• PACAPRPAC1
• pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
• pituitary adenylate cyclase-activating polypeptide type I receptor

Background

The PACAP receptor type 1, a member of the vasoactive intestinal polypeptide subfamily, binds the hormone pituitary adenylate cyclase activating polypeptide (PACAP) with high affinity. PACAP is involved in stimulating the secretion of insulin, catecholamines, ACTH, and growth hormone. Additionally, PACAP appears to function as a neuromodulator/neurotransmitter in the central and peripheral nervous systems. Two start codons are reported in literature, one (nt 74-76) results in a 525-amino acid protein with a signal peptide of 77 amino acids encoded by nt 74-304 and the second (nt 245-247) initiates a 468-amino acid protein with a signal peptide of 20-amino acids encoded by nt 245-304. The efficiency of these two start codons is not known. PACAP receptor type 1 expression has been documented in adipose, adrenal, bone, brain, colon, ganglion, heart, lung, ovary, pancreas, placenta, spleen, and uterus. ESTs have been isolated from brain and nerve libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADCYAP1R1
• Entrez:
  • 117(Human)
  • 11517(Mouse)
  • 24167(Rat)
• Uniprot:
  • P41586(Human)