PAC1R Products

Description

The PACAP receptor type 1, a member of the vasoactive intestinal polypeptide subfamily, binds the hormone pituitary adenylate cyclase activating polypeptide (PACAP) with high affinity. PACAP is involved in stimulating the secretion of insulin, catecholamines, ACTH, and growth hormone. Additionally, PACAP appears to function as a neuromodulator/neurotransmitter in the central and peripheral nervous systems. Two start codons are reported in literature, one (nt 74-76) results in a 525-amino acid protein with a signal peptide of 77 amino acids encoded by nt 74-304 and the second (nt 245-247) initiates a 468-amino acid protein with a signal peptide of 20-amino acids encoded by nt 245-304. The efficiency of these two start codons is not known. PACAP receptor type 1 expression has been documented in adipose, adrenal, bone, brain, colon, ganglion, heart, lung, ovary, pancreas, placenta, spleen, and uterus. ESTs have been isolated from brain and nerve libraries.

Bioinformatics

Entrez	117 Human
Product By Gene ID	117
Alternate Names	ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I PAC1R PACAP type I receptor PACAPR PACAP-R1 PACAP-R-1 PACAPRI PACAPRPAC1 pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop pituitary adenylate cyclase-activating polypeptide type I receptor

Research Areas for PAC1R

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
GPCR
Neuroscience
Neurotransmission
Signal Transduction