P2X7/P2RX7 Antibody (Hano43)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, ICC/IF
Clone
Hano43
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1 mg/ml

P2X7/P2RX7 Antibody (Hano43) Summary

Immunogen
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Specificity
This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
P2RX7
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:25-1:200
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Publications
Read Publication using NBP1-40894.

Reactivity Notes

Reacts with Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for P2X7/P2RX7 Antibody (Hano43)

  • ATP receptor
  • MGC20089
  • P2RX7
  • P2X purinoceptor 7
  • P2X7
  • P2X7P2X7 receptor
  • P2X7R
  • P2Z receptor
  • purinergic receptor P2X, ligand-gated ion channel, 7
  • purinergic receptor P2X7 variant A
  • Purinergic receptor

Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for P2X7/P2RX7 Antibody (NBP1-40894)(1)

We have publications tested in 1 confirmed species: Mouse.


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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-40894AF405
Alexa Fluor 488 Labeled NBP1-40894AF488
Alexa Fluor 647 Labeled NBP1-40894AF647
Alexa Fluor 700 Labeled NBP1-40894AF700
Allophycocyanin Labeled NBP1-40894APC
DyLight 350 Labeled NBP1-40894UV
DyLight 405 Labeled NBP1-40894V
DyLight 488 Labeled NBP1-40894G
DyLight 680 Labeled NBP1-40894FR
DyLight 755 Labeled NBP1-40894IR
PE Labeled NBP1-40894PE
PerCP Labeled NBP1-40894PCP

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Bioinformatics Tool for P2X7/P2RX7 Antibody (NBP1-40894)

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Diseases for P2X7/P2RX7 Antibody (NBP1-40894)

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Bioinformatics

Gene Symbol P2RX7
Entrez
Uniprot