P2X7/P2RX7 Antibody (Hano43) [Alexa Fluor® 350]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, ICC/IF
Clone
Hano43
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 350

Order Details

P2X7/P2RX7 Antibody (Hano43) [Alexa Fluor® 350] Summary

Immunogen
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Specificity
This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
P2RX7
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Reacts with Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for P2X7/P2RX7 Antibody (Hano43) [Alexa Fluor® 350]

  • ATP receptor
  • MGC20089
  • P2RX7
  • P2X purinoceptor 7
  • P2X7
  • P2X7P2X7 receptor
  • P2X7R
  • P2Z receptor
  • purinergic receptor P2X, ligand-gated ion channel, 7
  • purinergic receptor P2X7 variant A
  • Purinergic receptor

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for P2X7/P2RX7 Antibody (NBP1-40894AF350) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-40894AF350
Alexa Fluor 405 NBP1-40894AF405
Alexa Fluor 488 NBP1-40894AF488
Alexa Fluor 532 NBP1-40894AF532
Alexa Fluor 594 NBP1-40894AF594
Alexa Fluor 647 NBP1-40894AF647
Alexa Fluor 700 NBP1-40894AF700
Alexa Fluor 750 NBP1-40894AF750
Allophycocyanin NBP1-40894APC
Allophycocyanin/Cy7 NBP1-40894APCCY7
DyLight 350 NBP1-40894UV
DyLight 405 NBP1-40894V
DyLight 488 NBP1-40894G
DyLight 550 NBP1-40894R
DyLight 594 NBP1-40894DL594
DyLight 650 NBP1-40894C
DyLight 680 NBP1-40894FR
DyLight 755 NBP1-40894IR
Janelia Fluor 549 NBP1-40894JF549
Janelia Fluor 646 NBP1-40894JF646
PE NBP1-40894PE
PE/Atto594 NBP1-40894PEATT594
PE/Cy5.5 NBP1-40894PECY55
PE/Cy7 NBP1-40894PECY7
PerCP NBP1-40894PCP

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Bioinformatics Tool for P2X7/P2RX7 Antibody (NBP1-40894AF350)

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Bioinformatics

Gene Symbol P2RX7