P11 Antibody

Immunocytochemistry/Immunofluorescence: P11 Antibody [NB100-40907] - P11 in rat choroid plexus and FITC-conjugated donkey anti-chicken secondary antibodies

Product Discontinued

P11 Antibody Summary

• Immunogen: CNQKDPLAVDK
• Specificity: This is specific for the p11 protein.
• Isotype: IgY
• Clonality: Polyclonal
• Host: Chicken
• Gene: ENDOU
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Reacts with Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Notes

Chicken products cannot be exported to Canada.

Alternate Names for P11 Antibody

• EC 3.1
• endonuclease, polyU-specific
• MGC133268
• P11,26 serine protease
• Placental protein 11
• poly(U)-specific endoribonuclease
• PP1122 serine protease
• Protein endoU
• PRSS26
• Uridylate-specific endoribonuclease

Background

p11 increases localization of 5-HT1B receptors at the cell surface. It is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ENDOU
• Entrez:
  • 81778(Rat)