OCT6 Antibody

Product Discontinued

OCT6 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 300-350 of Human Oct-6.
• Marker: Schwann Cell Marker
• Specificity: Oct-6 (A332) detects endogenous levels of Oct-6 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: POU3F1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of Oct-6 (A332) pAb in extracts from A549 cell.
• Theoretical MW: 45 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for OCT6 Antibody

• Oct-6
• OCT6POU domain transcription factor SCIP
• Octamer-binding protein 6
• Octamer-binding transcription factor 6
• OTF6
• OTF-6
• POU class 3 homeobox 1
• POU domain class 3, transcription factor 1
• POU domain, class 3, transcription factor 1
• SCIP

Background

OCT6 homeodomain proteins are transcriptional regulators that function in various developmental processes (e.g. cell division, differentiation, specification and survival of specific cell types) and participate in the determination of cell fate. The 45 kDa OCT6 transcription factor Oct-6 (also designated SCIP and Tst-1) is expressed by late embryonic Schwann cells of the peripheral nervous system and is also expressed by nonmyelinating Schwann cells in adults. Oct-6 is strongly upregulated in promyelin cells because it is required for the timely differentiation of promyelin cells into myelinating cells. Oct-6 functions during myelination and is required for the proper downregulation of its own gene when myelination proceeds. c-Myc can act synergistically with the OCT6 domain of Oct-6 to produce myelin disease pathogenesis in the mammalian central nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: POU3F1
• Entrez:
  • 5453(Human)
  • 18991(Mouse)
  • 171068(Rat)
• Uniprot:
  • Q03052(Human)