NSUN2 Antibody [mFluor Violet 450 SE]

Product Discontinued

NSUN2 Antibody [mFluor Violet 450 SE] Summary

• Immunogen: NOL1/NOP2/Sun domain family, member 2. (Uniprot# Q08J23)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NSUN2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for NSUN2 Antibody [mFluor Violet 450 SE]

• EC 2.1.1
• EC 2.1.1.29
• FLJ20303,5-methycytoisine methyltransferase
• hTrm4
• member 2
• Myc-induced SUN-domain-containing protein
• NOL1/NOP2/Sun domain family 2
• NOL1/NOP2/Sun domain family member 2
• NOP2/Sun domain family, member 2
• SAKIMisu
• Substrate of AIM1/Aurora kinase B
• TRM4MISU
• tRNA (cytosine-5-)-methyltransferase NSUN2
• tRNA (cytosine-5-)-methyltransferase
• tRNA methyltransferase 4 homolog

Background

Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed 17071714]).[supplied by OMIM].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NSUN2