Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC, Mycoplasma
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed 17071714]).[supplied by OMIM].
Bioinformatics
| Uniprot |
Human
Human
|
| Product By Gene ID |
54888 |
| Alternate Names |
- EC 2.1.1
- EC 2.1.1.29
- FLJ20303,5-methycytoisine methyltransferase
- hTrm4
- member 2
- Myc-induced SUN-domain-containing protein
- NOL1/NOP2/Sun domain family 2
- NOL1/NOP2/Sun domain family member 2
- NOP2/Sun domain family, member 2
- SAKIMisu
- Substrate of AIM1/Aurora kinase B
- TRM4MISU
- tRNA (cytosine-5-)-methyltransferase NSUN2
- tRNA (cytosine-5-)-methyltransferase
- tRNA methyltransferase 4 homolog
|
