NPRA/NPR1 Antibody (488620) [Alexa Fluor® 350]

• Reactivity: Mu
• Applications: IHC
• Clone: 488620
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 350

NPRA/NPR1 Antibody (488620) [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse NPRA/NPR1
  Ser29-Glu469 (predicted)
  Accession # P18293
• Specificity: Detects mouse NPRA/NPR1 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NPRA/NPR1 Antibody (488620) [Alexa Fluor® 350]

• ANPa
• ANP-A
• ANPRA
• ANPR-A
• ANPRAEC 4.6.1.2
• atrial natriuretic peptide receptor 1
• Atrial natriuretic peptide receptor type A
• atrionatriuretic peptide receptor A
• GC-A
• Guanylate cyclase A
• GUC2A
• GUCY2A
• natriuretic peptide A type receptor
• natriuretic peptide receptor A
• natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptidereceptor A)
• NPR1
• NPRA
• NPR-A
• Pndr

Background

Mouse NPR1 (natriuretic peptide receptor-1; also ANP-R1 or guanlyl cyclase-A) is a 130 kDa member of the guanylyl cyclase family of proteins. It is a type I transmembrane glycoprotein that contains a 441 aa extracellular domain (ECD) (aa 29‑469) and a 567 aa cytoplasmic region. The cytoplasmic region shows a tyrosine kinase and guanylyl cyclase catalytic domain. NPR1 operates as an oligomer and binds both ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide). ANP binding induces bronchodilation and a reduction in blood pressure. Over aa 29‑469, mouse NPR1 is 97% and 86% aa identical to rat and human NPR1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.