NOA1 Antibody

Product Discontinued

NOA1 Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence ESDYCTAKGSEAIDR corresponding to internal region according to NP_115689.1.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NOA1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
• Application Notes: WB: Preliminary experiments gave an approx. 30 kDa band in human breast and in breast cancer lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 78.5 kDa band according to NP_115689.1. The 30 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for NOA1 Antibody

• chromosome 4 open reading frame 14
• hAtNOS1
• mAtNOS1
• MGC3232
• mitochondrial nitric oxide synthase
• nitric oxide synthase, mitochondrial (putative)
• putative ortholog of Arabidopsis mitochondrial nitric oxide synthase

Background

NOA1 is a gene that codes for a protein that is involved in the regulation of mitochondrial protein translation and respiration as well as mitochondria-mediated cell death, and is 698 amino acids long with a weight of approximately 78 kDa. Current research is being done on diseases and disorders related to this gene including pneumonia, adenocarcinoma, and malaria. NOA1 has also been shown to have interactions with AIFM1, GRB10, DAP3, HSPA8, and MPP3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NOA1 Antibody (NBP1-36942)(1)

Publication using NBP1-36942

• Parihar A, Parihar MS, Chen Z, Ghafourifar P. mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells. Life Sci 2008-05-23 [PMID: 18456285]

Bioinformatics

• Gene Symbol: NOA1
• Entrez:
  • 84273(Human)
  • 56412(Mouse)
  • 289562(Rat)
• Uniprot:
  • NP_115689.1(Human)