NIR2 Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

NIR2 Antibody Summary

Immunogen
Peptide with sequence C-KARSISLKLDSEE corresponding to C-Terminus according to NP_004901.2, NP_001124320.1.
Localization
Cytoplasmic
Specificity
This antibody is expected to recognise both reported isoforms.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PITPNM1
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:8000
Application Notes
WB: An anonymous customer has reported a band at approx. 160 kDa band in lysates of a mouse Macrophage cell line after 2ug/ml antibody staining (calculated MW of 135 kDa band according to NP_004901.1). ICC: An anonymous customer has reported staining of vesicular cytoplasm in the same cell line.
Publications
Read Publication using NB100-1417.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NIR2 Antibody

  • DRES9NIR-2
  • Drosophila retinal degeneration B homolog
  • FLJ44997
  • membrane-associated phosphatidylinositol transfer protein 1
  • NIR2PITPNM
  • phosphatidylinositol transfer protein, membrane-associated 1Pyk2 N-terminal domain-interacting receptor 2
  • PITPnm 1
  • Rd9
  • RDGB
  • RDGB1
  • RDGBA
  • RDGBA1
  • retinal degeneration B alpha 1

Background

NIR2 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. A specific Thr residue in the Nir2 PI-transfer domain provides a regulatory site for targeting to lipid droplets. This may affect intracellular lipid trafficking and distribution & explain the dominant effect of the RdgB-T59E mutant on retinal degeneration.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NB100-1417
Species: Mu
Applications: PEP-ELISA

Publications for NIR2 Antibody (NB100-1417)(1)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PITPNM1
Entrez
Uniprot