NGL-3/LRRC4B/LRCH4B Antibody (702008) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 702008
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

NGL-3/LRRC4B/LRCH4B Antibody (702008) [Alexa Fluor® 750] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human NGL-3/LRRC4B
  Ala47-Lys576
  Accession # Q9NT99
• Specificity: Detects human NGL-3/LRRC4B in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) LRRC3, rhLRRC4, or rhLRRC32 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NGL-3/LRRC4B/LRCH4B Antibody (702008) [Alexa Fluor® 750]

• DKFZp761A179
• HSM
• Leucine Rich Repeat Containing 4B
• Leucine-Rich Repeat-Containing Protein 4B
• Leucine-Rich Repeats And Immunoglobulin-Like Domains 4
• LRIG4
• LRRC4B
• Netrin-G3 Ligand
• NGL3
• NGL-3

Background

NGL-3 (netrin-G ligand-3), also called LRRC4B (Leu-rich repeat/LRR-containing glycoprotein 4B), is a 72 kDa (predicted) post-synaptic adhesion molecule of the LRR protein family. Mature human LRRC4B is a 678 amino acid (aa) type I transmembrane protein with a 541 aa extracellular region (aa 36-576) containing nine LRRs, a C2-type Ig-like domain, and a Thr-rich segment. Over the region used as an immunogen, human LRRC4B shares 97% aa sequence identity with mouse and rat LRRC4B. LRRC4B also shares ~55% aa identity with LRRC4C/NGL-1 and LRRC4/NGL-2, but each recognizes different ligands. LRRC4B recognition of the receptor tyrosine phosphatases LAR/PTPRF, PTPR-d and PTPR-s induces excitatory synapse formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.