NF2/Merlin Antibody

Western Blot: NF2/Merlin Antibody [H00004771-B02P] - Analysis of NF2 expression in transfected 293T cell line by NF2 polyclonal antibody. Lane 1: NF2 transfected lysate(55.77 KDa). Lane 2: Non-transfected lysate.

Immunocytochemistry/Immunofluorescence: NF2/Merlin Antibody [H00004771-B02P] - Analysis of purified antibody to NF2 on HeLa cell. (antibody concentration 10 ug/ml)

Product Discontinued

NF2/Merlin Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: NF2 (NP_861968.1, 1 a.a. - 507 a.a.) full-length human protein. MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: NF2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: It has been used for WB and IF.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for NF2/Merlin Antibody

• ACN
• BANF
• Merlin
• moesin-ezrin-radixin like
• Moesin-ezrin-radixin-like protein
• moesin-ezrin-radizin-like protein
• neurofibromin 2 (bilateral acoustic neuroma)
• neurofibromin 2 (merlin)
• neurofibromin-2
• NF2
• SCH
• Schwannomerlin
• Schwannomin

Background

Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NF2
• Entrez:
  • 4771(Human)
• Uniprot:
  • NP_861968.1(Human)