Neuromedin BR/NMBR Antibody - BSA Free

Immunohistochemistry-Paraffin: Neuromedin B R/NMBR Antibody [NLS825] - Human lung, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval dilution 16 ug/ml.

Immunohistochemistry-Paraffin: Neuromedin B R/NMBR Antibody [NLS825] - Analysis of anti-NMBR antibody with human brain olfactory bulb.

Immunohistochemistry-Paraffin: Neuromedin B R/NMBR Antibody [NLS825] - Analysis of anti-NMBR antibody with human brain, glioblastoma.

Immunohistochemistry-Paraffin: Neuromedin B R/NMBR Antibody [NLS825] - Human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: Neuromedin B R/NMBR Antibody [NLS825] - Human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Dilution 16 ug/ml.

• Reactivity: Hu, Mu, Po, Bt, Bv, Eq, Rb, Rt, Ca, Ha, Pm, Pm
• Applications: Flow, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Neuromedin BR/NMBR Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Neuromedin BR/NMBR.
• Epitope: 3rd cytoplasmic domain
• Specificity: Human NMBR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Rat (94%), Hamster (94%), Canine (94%), Primate (100%), Monkey (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NMBR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 - 10 ug/ml
• Application Notes: Use in Flow Cytometry reported in scientific literature (PMID:32807943).
• Control:

  Neuromedin BR/NMBR Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Xenopus (81%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Neuromedin BR/NMBR Antibody - BSA Free

• Neuromedin B R
• neuromedin B receptor
• Neuromedin BR
• neuromedin-B receptor
• Neuromedin-B-preferring bombesin receptor
• NMBR
• NMB-R

Background

The neuromedin B receptor, a Bombesin Receptor, activates phospholipase and protein kinase C and enhances calcium mobilization. It binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissues. Neuromedin B receptor expression has been reported in brain, particularly the olfactory bulb and thalamus, and in colon, liver, placenta, testis, spinal cord, and gastrointestinal tract. In addition, it has been shown to be present in cancer of the lung, ovary, and prostate. ESTs have been isolated from B-cell/lung/testis and brain libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Neuromedin BR/NMBR Antibody (NLS825)(1)

Publication using NLS825

• Inclan-Rico JM, Ponessa JJ, Valero-Pacheco N et al. Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol. 2020-08-17 [PMID: 32807943] (FLOW, Mouse)

Bioinformatics

• Gene Symbol: NMBR
• Entrez:
  • 4829(Human)